INT248940

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.45
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 5
Klrd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 66 87.84 High High
tolerance 12 17.16 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 42 98.64 Very High Very High Very High
Hypersensitivity 30 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chattopadhyay et al[18] extended this study and reported that mice with deficiency of CD94-NKG2A were unable to develop ACAID, and CD8+T cells from these mice did not transfer the local suppression of a DTH response.
Negative_regulation (deficiency) of CD94 in T cells associated with hypersensitivity
1) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.10 Pain Relevance 0
Chattopadhyay[18] et al demonstrated that DBA/2J mice, characterized by a deficiency in CD94/NKG2A, showed a defective immune regulation by CD8+Treg response in vivo following intracameral antigen inoculation.
Negative_regulation (deficiency) of CD94
2) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0
A positive selection was performed and both CD8+CD94+T and CD8+CD94-T cells were isolated as described by the manufacturer.
Negative_regulation (isolated) of CD94 in T cells
3) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07
As shown in Figure 5C, neutralization of TGF-beta1 was able to decrease the CD8+CD94+T cell suppressive activity by 27.4%.
Negative_regulation (decrease) of CD94 in T cell
4) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0
As both intracameral inoculation and conventional immunization could upregulate CD94-NKG2A expression, we examined the inhibitory effect of CD8+CD94+T cells from ACAID mice and immunized mice on the proliferation of splenic MNC in vitro.
Spec (examined) Negative_regulation (effect) of CD94 in T cells associated with immunization
5) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.10 Pain Relevance 0
A positive selection was performed and both CD8+CD94+T and CD8+CD94-T cells were isolated as described by the manufacturer.
Negative_regulation (isolated) of CD94 in T cells
6) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07

General Comments

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