INT248951

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
Cd8a (Mus musculus)
Klrd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 44 89.88 High High
tolerance 8 42.96 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 28 76.56 Quite High
Hypersensitivity 20 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, a few studies reported that CD94 was associated with the regulatory function of NK cells and CD8+T cells.
CD8 Binding (associated) of CD94 in T cells
1) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.14 Pain Relevance 0
However, it appears that CD94 is not a specific marker for CD8+Treg, as this molecule can be upregulated following T cell activation and CD8+CD94+T cells from immunized mice did not show suppression.
CD8 Neg (not) Binding (marker) of CD94 in T cells
2) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07
Although CD94 could pair with different NKG2 molecules, most CD94/NKG2 receptors on both NK and CD8+T cells have been shown to be CD94-NKG2A heterodimer in mice [8,11].
CD8 Binding (heterodimer) of CD94 in T cells
3) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0.06
Recently, a few studies reported that CD94 was associated with the regulatory function of NK cells and CD8+T cells.
CD8 Binding (associated) of CD94 in T cells
4) Confidence 0.26 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.14 Pain Relevance 0

General Comments

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