INT248973

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 2.19
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
ependymal cell 2
inner nuclear layer 2
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 903 100.00 Very High Very High Very High
GABA receptor 63 99.20 Very High Very High Very High
agonist 196 98.52 Very High Very High Very High
antagonist 196 97.64 Very High Very High Very High
Action potential 125 93.84 High High
Glutamate 91 92.40 High High
Neurotransmitter 161 89.08 High High
Dopamine 525 85.60 High High
dopamine receptor 28 85.44 High High
GABAergic 92 84.80 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 560 99.68 Very High Very High Very High
Ganglion Cysts 183 98.64 Very High Very High Very High
Targeted Disruption 23 26.48 Quite Low
Dislocations 22 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 16 5.00 Very Low Very Low Very Low
Decapitation 14 5.00 Very Low Very Low Very Low
Body Weight 14 5.00 Very Low Very Low Very Low
Weight Loss 7 5.00 Very Low Very Low Very Low
Refractive Errors 7 5.00 Very Low Very Low Very Low
Retina Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the substantial reduction in PER2::LUC expression upon GABA treatment is likely due to posttranscriptional regulation.
Negative_regulation (reduction) of Gene_expression (expression) of LUC associated with gaba
1) Confidence 0.08 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.54
To test whether casein kinases are involved in the inhibitory effect of GABA on PER2::LUC levels and retinal rhythms, we applied the casein kinase inhibitor CKI-7 (50 ?
Spec (whether) Negative_regulation (inhibitory) of Gene_expression (levels) of LUC associated with gaba
2) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.57
Retinal PER2::LUC rhythms also persisted during continuous application of the D1 receptor agonist SKF-38393 and the D2/D4 receptor agonist quinpirole hydrochloride (50 ?
Negative_regulation (persisted) of Gene_expression (rhythms) of LUC associated with agonist
3) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.68
The wide distribution of PER2::LUC expression across the inner nuclear layer suggests that multiple inner nuclear layer cell types are sources for the rhythmic PER2::LUC signal and are likely participants in the inner retinal clock mechanism.
Negative_regulation (distribution) of Gene_expression (expression) of LUC in inner nuclear layer
4) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.12
However, retinal PER2::LUC rhythms persisted during blockade of GABA receptors with the GABAA receptor antagonist SR-95531 (40 ?
Negative_regulation (persisted) of Gene_expression (rhythms) of LUC associated with antagonist and gaba receptor
5) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.71
However, retinal PER2::LUC rhythms persisted during blockade of GABA receptors with the GABAA receptor antagonist SR-95531 (40 ?
Negative_regulation (retinal) of Gene_expression (rhythms) of LUC associated with antagonist and gaba receptor
6) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.71
However, the amplitude of PER2::LUC rhythms was largely unaffected by the GABAB agonist baclofen (200 ?
Negative_regulation (amplitude) of Gene_expression (rhythms) of LUC associated with agonist
7) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.66
Circadian rhythmicity in PER2::LUC expression was observed in all slices and was sustained for ~1 week (mean ± SEM: 6.9 ± 1.0; Fig. 2B, Table 1).
Negative_regulation (rhythmicity) of Gene_expression (expression) of LUC
8) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0 Pain Relevance 0
All recordings revealed clear PER2::LUC expression in the DMH, primarily in the pars compacta region (DMHc), in the Arc, ME/PT and in the ependymal cell layer of the third ventricle, but surprisingly, not in the VMH.
Negative_regulation (revealed) of Gene_expression (expression) of LUC in ependymal cell associated with aids-related complex
9) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.25 Pain Relevance 0
PER2::LUC expression was observed in the ME/PT in all MBH slices and was often clearly delineated in the PT region.
Negative_regulation (delineated) of Gene_expression (expression) of LUC
10) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0 Pain Relevance 0
Rayleigh vector plots indicated that, unlike in the SCN, the phase of peak PER2::LUC expression in the Arc and DMH was significantly correlated with time of cull (p < 0.00001; see additional file 1: Fig.
Negative_regulation (phase) of Gene_expression (expression) of LUC associated with aids-related complex
11) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.61 Pain Relevance 0
Circadian rhythms of PER2::LUC expression imaged in the SCN
Negative_regulation (rhythms) of Gene_expression (expression) of LUC
12) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.15 Pain Relevance 0
Intact MBH slice cultures were initially imaged on the EM-CCD camera to confirm the location of PER2::LUC expression in the Arc, ME/PT and DMH, and then placed in PMTs.
Negative_regulation (location) of Gene_expression (expression) of LUC associated with aids-related complex
13) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.63 Pain Relevance 0
PMT recordings of PER2::LUC bioluminescence expression in the SCN were assessed for comparison with the MBH.
Negative_regulation (recordings) of Gene_expression (expression) of LUC
14) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.45 Pain Relevance 0
These data corroborate a comprehensive study by Yoshikawa and colleagues (2005), who demonstrated that the time of peak per1::luc expression in the SCN was delayed when cultures from rats previously held under a LD cycle were prepared in the night or early day versus the middle of the day.
Negative_regulation (delayed) of Gene_expression (expression) of luc
15) Confidence 0.01 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0

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