INT248974

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) nucleus (Per1) protein binding transcription factor activity (Per1)
cytoplasm (Per1) signal transducer activity (Per1)
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 129 95.18 Very High Very High Very High
Dopamine 75 86.24 High High
Neurotransmitter 23 78.92 Quite High
GABAergic 13 75.08 Quite High
Glutamate receptor 2 37.52 Quite Low
GABA receptor 9 26.16 Quite Low
antagonist 28 5.00 Very Low Very Low Very Low
agonist 28 5.00 Very Low Very Low Very Low
tetrodotoxin 22 5.00 Very Low Very Low Very Low
Action potential 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 80 99.08 Very High Very High Very High
Weight Gain 1 6.52 Low Low
Body Weight 2 6.32 Low Low
Ganglion Cysts 26 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Refractive Errors 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that GABA could, through membrane hyperpolarization and activation of casein kinase, stimulate the degradation of accumulated PER proteins on the falling phase of their rhythm (which roughly corresponds to the night state), acting to remove feedback inhibition on Per transcription and thereby preparing retinal oscillators for transcriptional activation that characterizes the “day” state.
Negative_regulation (inhibition) of Transcription (transcription) of Per associated with gaba
1) Confidence 0.48 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.60
Abe and colleagues demonstrated intrinsic rhythmicity of per1 mRNA expression in cultures of ME and Arc prepared from per1::luc rats, though such PMT recordings lack the capacity for precise anatomical or cellular localization of the oscillations [15].
Negative_regulation (rhythmicity) of Transcription (expression) of per1 associated with aids-related complex
2) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.33 Pain Relevance 0

General Comments

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