INT248989

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ptar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABA receptor 27 99.20 Very High Very High Very High
gABA 387 98.32 Very High Very High Very High
agonist 84 94.32 High High
GABAergic 39 92.72 High High
antagonist 84 82.48 Quite High
addiction 9 57.12 Quite High
Dopamine 225 50.00 Quite Low
Neurotransmitter 69 5.00 Very Low Very Low Very Low
Glutamate 39 5.00 Very Low Very Low Very Low
Action potential 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 78 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Myopia 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low
Refractive Errors 3 5.00 Very Low Very Low Very Low
Retina Disease 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Ocular Hypertension 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABA receptors are classified as ionotropic, chloride-conducting GABAA and GABAC receptors, or as metabotropic GABAB receptor.
Neg (unaffected) Positive_regulation (conducting) of GABAC associated with gaba receptor
1) Confidence 0.00 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.76
These results indicate that activation of both GABAA and GABAC receptors is necessary to mimic fully the action of GABA on retinal rhythms, with GABAB receptors playing no apparent role, either alone or in combination with the other receptors.
Positive_regulation (activation) of GABAC associated with gaba
2) Confidence 0.00 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.70
Taken together, these pharmacological studies indicate that endogenous retinal GABA reduces PER2::LUC signals and the amplitude of molecular retinal circadian rhythms through activation of both GABAA and GABAC receptors.


Positive_regulation (activation) of GABAC associated with gaba
3) Confidence 0.00 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.51

General Comments

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