INT2490

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2009
Negated 3
Speculated 9
Reported most in Abstract
Documents 44
Total Number 54
Disease Relevance 9.45
Pain Relevance 13.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
plasma 3
exocrine pancreas 2
rectum 2
blood 2
forestomach 2
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 28 100.00 Very High Very High Very High
Analgesic 24 100.00 Very High Very High Very High
anesthesia 11 100.00 Very High Very High Very High
Cholecystokinin 11 100.00 Very High Very High Very High
Antinociceptive 7 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Raphe 3 100.00 Very High Very High Very High
Pain 11 99.96 Very High Very High Very High
qutenza 31 99.82 Very High Very High Very High
Neurotransmitter 2 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 38 100.00 Very High Very High Very High
Disease 9 100.00 Very High Very High Very High
Pancreatic Cancer 6 100.00 Very High Very High Very High
Pain 11 99.96 Very High Very High Very High
Duodenal Ulcer 3 99.38 Very High Very High Very High
Cancer 6 99.22 Very High Very High Very High
Metastasis 4 99.04 Very High Very High Very High
Aggression 1 98.68 Very High Very High Very High
Rheumatoid Arthritis 3 98.56 Very High Very High Very High
Osteoporosis 3 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that vagal input may affect the action of secretin by modulating the level of secretin receptor in the forestomach.
Spec (may) Regulation (affect) of secretin in forestomach
1) Confidence 0.62 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10198350 Disease Relevance 0 Pain Relevance 0.26
We conclude that secretin inhibits the motility of the possum SO in a nonuniform manner and is modulated by neural activity.
Regulation (modulated) of secretin in neural
2) Confidence 0.50 Published 2001 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 11696106 Disease Relevance 0 Pain Relevance 0.33
These nine neurons also showed no response to administration of secretin.
Neg (no) Regulation (response) of secretin in neurons
3) Confidence 0.45 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15920018 Disease Relevance 0 Pain Relevance 0.09
We hypothesized that vagal input may affect the action of secretin by modulating the level of secretin receptor in the forestomach.
Regulation (modulating) of secretin in forestomach
4) Confidence 0.45 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10198350 Disease Relevance 0 Pain Relevance 0.32
We studied the effects of intracerebroventricularly (ICV) administered salmon calcitonin (sCT) on the self-mutilation behavior (autotomy) of rats after dorsal rhizotomy. sCT was given 2 micrograms/rat ICV, on alternate days) from day 15 to day 40 after surgery and autotomy was scored until day 60.
Regulation (effects) of sCT in dorsal associated with dorsal rhizotomy
5) Confidence 0.45 Published 1992 Journal Pain Section Abstract Doc Link 1589247 Disease Relevance 0.07 Pain Relevance 0.25
The role of the serotonergic system in the antinociceptive effect of centrally administered salmon calcitonin (sCT) was studied in rats.
Regulation (role) of sCT associated with antinociceptive
6) Confidence 0.45 Published 1986 Journal Neuropeptides Section Abstract Doc Link 2946979 Disease Relevance 0 Pain Relevance 0.17
Following this pilot study a randomised controlled trial of Secretin vs placebo would be appropriate.
Regulation (controlled) of Secretin
7) Confidence 0.45 Published 2001 Journal Br Homeopath J Section Abstract Doc Link 11341462 Disease Relevance 0.58 Pain Relevance 0.13
Recent controlled trials of secretin have not shown efficacy compared to placebo.
Regulation (controlled) of secretin
8) Confidence 0.44 Published 2000 Journal Harv Rev Psychiatry Section Abstract Doc Link 10902094 Disease Relevance 0.79 Pain Relevance 0.16
The effect of secretin on pancreatic blood flow in the awake and anesthetized dog.
Regulation (effect) of secretin in blood associated with anesthesia
9) Confidence 0.44 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 6889320 Disease Relevance 0 Pain Relevance 0.26
The effect of peripherally administered cyproheptadine or reserpine and the administration of 5,7-dihydroxytryptamine (5,7-DHT) in the nucleus raphe dorsalis on the analgesic activity of salmon calcitonin (sCT) injected into the lateral ventricle were investigated in male rats.
Spec (investigated) Regulation (effect) of sCT in nucleus associated with analgesic and raphe
10) Confidence 0.44 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3979435 Disease Relevance 0 Pain Relevance 0.40
An investigation was made of the effects of phorbol esters, 12-O-tetradecanoylphorbol acetate (TPA) and secretin on pancreatic juice secretion in the anaesthetized rat.
Regulation (effects) of secretin
11) Confidence 0.44 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2379800 Disease Relevance 0 Pain Relevance 0.03
The release and physiological actions of secretin on pancreatic exocrine secretion and gastric secretion of acid and motility are regulated by neuro-hormonal control.
Regulation (regulated) of secretin
12) Confidence 0.42 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.32
To define the role of inorganic electrolyte secretion in hepatic bile formation, the effects of secretin, glucagon, and differently structured bile acids on bile flow and composition were studied in the dog, guinea pig, and rat.
Regulation (effects) of secretin in bile associated with bile
13) Confidence 0.42 Published 1985 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 4075249 Disease Relevance 0 Pain Relevance 0.36
Hospitalized male patients with endoscopically verified duodenal ulcer were studied to determine the effect of secretin on the clinical course of their disease.
Spec (determine) Regulation (effect) of secretin associated with duodenal ulcer and disease
14) Confidence 0.41 Published 1976 Journal Am J Dig Dis Section Abstract Doc Link 790943 Disease Relevance 0.45 Pain Relevance 0.05
Effects of secretin infusion on myocardial performance and metabolism in the dog.
Regulation (Effects) of secretin associated with anesthesia
15) Confidence 0.40 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2418308 Disease Relevance 0.08 Pain Relevance 0.10
The purpose of the present study was to investigate the effects of sCT, injected directly into the lateral cerebral ventriculi, on the firing of single nociceptive thalamic neurons, detected by electrophysiological techniques in an experimental model of prolonged or chronic pain, such as rats rendered arthritic by injection of Freund's adjuvant into the left hindfoot.
Spec (investigate) Regulation (effects) of sCT in neurons associated with nociception, lasting pain and arthritis
16) Confidence 0.39 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469441 Disease Relevance 0.45 Pain Relevance 0.39
Effects of phorbol esters and secretin on pancreatic juice secretion in the anaesthetized rat.
Regulation (Effects) of secretin associated with anesthesia
17) Confidence 0.38 Published 1990 Journal Gen. Pharmacol. Section Title Doc Link 2379800 Disease Relevance 0 Pain Relevance 0.17
Response of the exocrine pancreas to graded doses of secretin in calcium-treated and normal dogs.
Regulation (Response) of secretin in exocrine pancreas
18) Confidence 0.38 Published 1981 Journal Regul. Pept. Section Title Doc Link 7255771 Disease Relevance 0.19 Pain Relevance 0.05
Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic carcinoma and pancreatitis.
Regulation (Effect) of secretin in plasma associated with bile, pancreatitis, pancreatic cancer and cholecystokinin
19) Confidence 0.36 Published 1979 Journal Cancer Section Title Doc Link 455230 Disease Relevance 0.70 Pain Relevance 0.30
Plasma CEA concentration before and after administration of secretin and cholecystokinin-pancreozymin has been determined in 89 patients with neoplastic or inflammatory pancreatric disease and other neoplastic and nonneoplastic disorders.
Regulation (concentration) of secretin in Plasma associated with bile, inflammation, disease and cholecystokinin
20) Confidence 0.36 Published 1979 Journal Cancer Section Abstract Doc Link 455230 Disease Relevance 0.41 Pain Relevance 0.22

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