INT249005

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) transport (Gabrg1) nucleus (Per2)
protein binding transcription factor activity (Per2) plasma membrane (Gabrg1) cytoplasm (Per2)
Gabrg1 (Mus musculus)
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 387 100.00 Very High Very High Very High
GABAergic 39 83.68 Quite High
antagonist 84 77.60 Quite High
GABA receptor 27 66.04 Quite High
addiction 9 60.96 Quite High
Dopamine 225 50.00 Quite Low
agonist 84 34.48 Quite Low
dopamine receptor 12 20.96 Low Low
Neurotransmitter 69 5.00 Very Low Very Low Very Low
Glutamate 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 78 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Myopia 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low
Refractive Errors 3 5.00 Very Low Very Low Very Low
Retina Disease 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Ocular Hypertension 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these pharmacological studies indicate that endogenous retinal GABA reduces PER2::LUC signals and the amplitude of molecular retinal circadian rhythms through activation of both GABAA and GABAC receptors.


GABA Positive_regulation (reduces) of PER2 associated with gaba
1) Confidence 0.39 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.51
Interestingly, GABA did not change the mRNA levels of Per2 and Clock, but did increase the mRNA levels of Per1 and Bmal1 (Figure 10A).
GABA Neg (not) Positive_regulation (change) of Per2 associated with gaba
2) Confidence 0.36 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.54
However, GABA did not significantly change the period of retinal PER2::LUC rhythms compared with vehicle (?
GABA Neg (not) Positive_regulation (change) of period associated with gaba
3) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.66

General Comments

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