INT249013

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.07
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) transport (Gabrg1) nucleus (Per2)
protein binding transcription factor activity (Per2) plasma membrane (Gabrg1) cytoplasm (Per2)
Anatomy Link Frequency
retina 2
Gabrg1 (Mus musculus)
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 516 100.00 Very High Very High Very High
GABA receptor 36 92.04 High High
GABAergic 52 88.08 High High
antagonist 112 82.72 Quite High
agonist 112 82.08 Quite High
Neurotransmitter 92 69.12 Quite High
Action potential 52 65.36 Quite High
Dopamine 300 50.00 Quite Low
tetrodotoxin 36 44.08 Quite Low
Glutamate 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 104 73.52 Quite High
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Myopia 4 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low
Refractive Errors 4 5.00 Very Low Very Low Very Low
Retina Disease 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Ocular Hypertension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that GABA acts, in part, by stimulating casein kinase to suppress PER2 levels.


GABA Negative_regulation (suppress) of PER2 associated with gaba
1) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.40
To determine the mechanisms by which GABA suppressed retinal PER2::LUC expression and rhythmicity, we first quantified Per1, Per2, Clock, and Bmal1 mRNA levels 8 h after 3 mM GABA treatment using quantitative real-time PCR.
GABA Negative_regulation (suppressed) of PER2 associated with gaba
2) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.50
Therefore, GABA-induced inhibition of ensemble PER2::LUC rhythms is retina specific.


GABA Negative_regulation (inhibition) of PER2 in retina associated with gaba
3) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.81
However, the ability of exogenous GABA to suppress substantially PER2::LUC rhythms is unique to the retina, as similar experiments with SCN slices do not yield similar results.
GABA Negative_regulation (suppress) of PER2 in retina associated with gaba
4) Confidence 0.29 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.07 Pain Relevance 0.59

General Comments

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