INT24902

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Context Info
Confidence 0.71
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 8.11
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
syncytiotrophoblast 2
embryos 1
testis 1
nucleus 1
SW-480 1
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
mu opioid receptor 40 99.88 Very High Very High Very High
COX-2 inhibitor 3 93.28 High High
cytokine 99 83.00 Quite High
Morphine 10 74.16 Quite High
cINOD 8 73.56 Quite High
addiction 8 72.32 Quite High
abdominal pain 6 59.20 Quite High
Inflammation 86 50.00 Quite Low
chemokine 76 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 127 99.02 Very High Very High Very High
Reprotox - General 1 37 96.44 Very High Very High Very High
Ectopic Pregnancy 190 95.48 Very High Very High Very High
Repression 10 95.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 151 94.32 High High
Colon Cancer 8 93.44 High High
Respiratory Syncytial Virus 200 93.08 High High
Immunodeficiency 19 91.60 High High
Syndrome 8 77.08 Quite High
Oligohydramnios 1 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, it was demonstrated that SIV (SIVmac239) infection may result in gradual reduction of the MOR gene expression and Sp1 during a period of 48 h postinfection by analysis of quantitative real-time RT-PCR and Western blotting.
Gene_expression (expression) of Sp1 associated with mu opioid receptor and infection
1) Confidence 0.71 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.71 Pain Relevance 0.36
The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.
Gene_expression (contributed) of Sp1
2) Confidence 0.62 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.77 Pain Relevance 0.37
The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.
Gene_expression (contributed) of Sp1
3) Confidence 0.62 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.75 Pain Relevance 0.35
All of them had depressed hCG, SP1 and PAPP-A levels.
Gene_expression (levels) of SP1
4) Confidence 0.56 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.50 Pain Relevance 0.06
Transfection with Sp1-expressing vector (PN3-Sp1) was also able to enhance the activity of the promoter in SIVmac239-infected cells.
Gene_expression (Transfection) of Sp1-expressing
5) Confidence 0.55 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.73 Pain Relevance 0.39
Transfection with Sp1-expressing vector (PN3-Sp1) was also able to enhance the activity of the promoter in SIVmac239-infected cells.
Gene_expression (Transfection) of Sp1
6) Confidence 0.55 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.74 Pain Relevance 0.39
All 10 women showed strong hCG and SP-1 staining in the syncytiotrophoblast that was apparently unrelated to maternal levels of hCG and SP-1.
Gene_expression (levels) of SP-1 in syncytiotrophoblast
7) Confidence 0.54 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.90 Pain Relevance 0
All 10 women showed strong hCG and SP-1 staining in the syncytiotrophoblast that was apparently unrelated to maternal levels of hCG and SP-1.
Gene_expression (staining) of SP-1 in syncytiotrophoblast
8) Confidence 0.47 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.98 Pain Relevance 0
B, AP-1, and NFAT proteins are constitutively localized in the nucleus, and the activator Sp1 expression predominates over the repressor Sp3, resulting in greater availability of Sp1 (Fig. 7).
Gene_expression (expression) of Sp1 in nucleus
9) Confidence 0.20 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.28 Pain Relevance 0.03
Treatment of SW-480 cells with Cel, NM, and NS also decreased Sp1 and Sp4 protein expression but not that of Sp2 or Sp3.
Gene_expression (expression) of Sp1 in SW-480
10) Confidence 0.14 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.48 Pain Relevance 0.23
On the other hand, many researchers have found that transcription factors (e.g., c-Myb, c-Myc/Myn, E2F, CREB, Ap1, Ap2, Sp1, and NF-?
Gene_expression (e.g.) of Sp1
11) Confidence 0.14 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 0.24 Pain Relevance 0
On the other hand, many researchers have found that transcription factors (e.g., c-Myb, c-Myc/Myn, E2F, CREB, Ap1, Ap2, Sp1, and NF-?
Gene_expression (/) of Sp1
12) Confidence 0.14 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 0.24 Pain Relevance 0
g of nuclear extract was performed using rabbit antibodies against Sp1 and the p50 and p65 subunits of NF-?
Gene_expression (using) of Sp1
13) Confidence 0.11 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.14 Pain Relevance 0.16
g of nuclear extract was performed using rabbit antibodies against Sp1 and the p50 and p65 subunits of NF-?
Gene_expression (subunits) of Sp1
14) Confidence 0.11 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.20 Pain Relevance 0.16
Other signalling pathways and elements have been proposed to mediate ROS-dependent collagen type I expression, including up-regulation of cyclooxygenase 2 [311] or the redox sensitive transcription factor Sp-1 [304,314], but it should be noted that again the H2O2-dependent involvement of the same C/EBP?
Gene_expression (expression) of Sp-1 associated with cox2
15) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.10 Pain Relevance 0.09
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Gene_expression (fractions) of Specificity protein 1
16) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0
Relative to the other SpREJ transcripts, SpREJ1 is highly expressed only in testis [5] and the same is true for SpREJ6 expression in muscle/test.
Gene_expression (expressed) of SpREJ1 in testis
17) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0
Under our experimental conditions, the expression of SpREJ1 and 6 were not detectable in early embryos.
Gene_expression (expression) of SpREJ1 in embryos
18) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0

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