INT24903

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.98
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)
Anatomy Link Frequency
plasma 2
PAPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 100.00 Very High Very High Very High
abdominal pain 3 99.70 Very High Very High Very High
metalloproteinase 7 63.52 Quite High
methotrexate 1 30.84 Quite Low
pain pelvic 2 14.04 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 5 100.00 Very High Very High Very High
Coronary Artery Disease 3 100.00 Very High Very High Very High
Abdominal Pain 3 99.70 Very High Very High Very High
Reprotox - General 1 19 99.38 Very High Very High Very High
Ectopic Pregnancy 95 99.02 Very High Very High Very High
Down Syndrome 4 98.96 Very High Very High Very High
Tubal Pregnancy 10 93.36 High High
Diabetes Mellitus 1 92.64 High High
Pre-eclampsia 1 91.80 High High
Threatened Abortion 2 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maternal serum levels of PAPP-A in the first trimester are significantly reduced when a fetus affected by Down syndrome is present.
Negative_regulation (reduced) of Gene_expression (levels) of PAPP-A associated with down syndrome
1) Confidence 0.42 Published 2002 Journal Bratisl Lek Listy Section Abstract Doc Link 12448565 Disease Relevance 0.74 Pain Relevance 0.19
All of them had depressed hCG, SP1 and PAPP-A levels.
Negative_regulation (depressed) of Gene_expression (levels) of PAPP-A
2) Confidence 0.41 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.50 Pain Relevance 0.06
AIMS: To assess, in chronic stable angina (CSA) patients, the relationship among clinical characteristics and cardiovascular risk factors, extent of coronary artery disease (CAD), and pregnancy-associated plasma protein-A (PAPP-A) levels.
Negative_regulation (assess) of Gene_expression (levels) of PAPP-A in plasma associated with angina and coronary artery disease
3) Confidence 0.41 Published 2005 Journal Eur. Heart J. Section Abstract Doc Link 16055491 Disease Relevance 0.45 Pain Relevance 0.17
A similar pattern was observed in PAPP-A levels with significant reduction after 12 hours (p<0.01).
Negative_regulation (observed) of Gene_expression (levels) of PAPP-A
4) Confidence 0.41 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: AMI patients treated with PCI had an early significant reduction in MMP-9, MMP-9/TIMP-1 ratio and PAPP-A when compared to patients with stable angina pectoris treated with PCI.
Negative_regulation (reduction) of Gene_expression (ratio) of PAPP-A
5) Confidence 0.41 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.06 Pain Relevance 0
The authors indicated that clinical evidence of EP (vaginal bleeding, abdominal pain) and severely decreased or absent serum PAPP-A levels in women with a positive pregnancy test suggest a diagnosis of EP as the main possibility.
Negative_regulation (decreased) of Neg (absent) Gene_expression (levels) of PAPP-A associated with abdominal pain, ectopic pregnancy and reprotox - general 1
6) Confidence 0.41 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.15 Pain Relevance 0.10

General Comments

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