INT24904

Context Info Confidence 0.57 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 9.93 Pain Relevance 2.74

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)

Anatomy Link Frequency plasma 3 coronary artery 1 PAPPA (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 9 100.00 Angina 14 97.00 Codeine 18 95.60 Oxycodone 1 94.88 ischemia 4 89.76 Opioid 63 89.44 abdominal pain 8 85.92 Inflammatory marker 8 82.80 Bioavailability 2 82.08 Analgesic 41 78.72

Disease Link Frequency Relevance Heat Rhinitis 1 100.00 Myocardial Infarction 15 99.72 Ectopic Pregnancy 285 99.68 Acute Coronary Syndrome 34 99.24 Down Syndrome 4 98.96 Reprotox - General 1 52 98.90 Tubal Pregnancy 30 98.52 Oligohydramnios 2 98.52 Coronary Heart Disease 2 98.44 Coronary Artery Disease 17 97.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In 34 women missed miscarriage was diagnosed readily by ultrasound; all but five had depressed hCG and PAPP-A levels.

Negative_regulation (depressed) of PAPP-A associated with reprotox - general 1

1) Confidence 0.57 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.54 Pain Relevance 0.07

CONCLUSION: AMI patients treated with PCI had an early significant reduction in MMP-9, MMP-9/TIMP-1 ratio and PAPP-A when compared to patients with stable angina pectoris treated with PCI.

Negative_regulation (reduction) of PAPP-A

2) Confidence 0.57 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.06 Pain Relevance 0

High-dose atorvastatin significantly decreased PAPP-A at 1 month and hs-CRP at 6 months in patients with verified CAD.

Negative_regulation (decreased) of PAPP-A associated with coronary artery disease

3) Confidence 0.57 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18157962 Disease Relevance 1.04 Pain Relevance 0.11

Patients randomly assigned to atorvastatin 10 mg did not show a significant decrease in PAPP-A from baseline at 1 or 6 months.

Negative_regulation (decrease) of PAPP-A

4) Confidence 0.57 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18157962 Disease Relevance 1.12 Pain Relevance 0.16

Maternal serum levels of PAPP-A in the first trimester are significantly reduced when a fetus affected by Down syndrome is present.

Negative_regulation (reduced) of PAPP-A associated with down syndrome

5) Confidence 0.57 Published 2002 Journal Bratisl Lek Listy Section Abstract Doc Link 12448565 Disease Relevance 0.74 Pain Relevance 0.19

On univariate analysis, male gender (P<0.001), age (P<0.001), previous history of myocardial infarction (P=0.013), reduced ejection fraction (P<0.001), severe coronary artery disease (P<0.001), aspirin treatment (P<0.001), PAPP-A levels (P<0.001), and PAPP-A/proMBP ratio (P<0.001) were correlated with the number of complex stenoses.

Negative_regulation (reduced) of PAPP-A in coronary artery

6) Confidence 0.42 Published 2004 Journal Circulation Section Body Doc Link 15023879 Disease Relevance 0.07 Pain Relevance 0

UNLABELLED: The objective of this study was to investigate the time profiles of plasma matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases (TIMP-1 and -2), and pregnancy associated plasma protein A (PAPP-A) in patients with acute myocardial infarction (AMI), compared to patients with stable angina pectoris (AP), all treated with percutaneous coronary intervention (PCI) with stent.

Negative_regulation (inhibitor) of PAPP-A in plasma associated with stable angina pectoris, angina, metalloproteinase and myocardial infarction

7) Confidence 0.42 Published 2009 Journal Thromb. Res. Section Abstract Doc Link 19410278 Disease Relevance 0.35 Pain Relevance 0.31

Although PAPP-A levels were found to be lower in individuals with ectopic pregnancies and intrauterine abortions compared to those with normal pregnancies, PAPP-A measurements cannot be used to distinguish between EP and intrauterine abortion.35 Tornehave et al. examined the tissue distribution and intensity of immunohistochemical staining for hCG, SP-1, and PAPP-A in trophoblastic and decidualized endometrial tissues of 10 women with EP.

Negative_regulation (lower) of PAPP-A associated with ectopic pregnancy and reprotox - general 1

8) Confidence 0.42 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.47 Pain Relevance 0.07

Serum PAPP-A levels were lower in the EP and intrauterine abortion groups compared to the normal pregnancy group; they were undetectable in 82% of the EP group and 55% of the intrauterine abortion group.

Negative_regulation (lower) of PAPP-A associated with ectopic pregnancy and reprotox - general 1

9) Confidence 0.42 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.51 Pain Relevance 0.08

A live fetus was demonstrated in 259 women of whom six subsequently miscarried; one of these had markedly depressed serum hCG and PAPP-A, but normal SP1 levels, and two had oligohydramnios.

Negative_regulation (depressed) of PAPP-A associated with oligohydramnios

10) Confidence 0.41 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.57 Pain Relevance 0.09

The authors measured PAPP-A, hCG, and SP1 concentrations in 164 serum samples and 29 tissue samples obtained from these women.

Negative_regulation (measured) of PAPP-A

11) Confidence 0.41 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.85 Pain Relevance 0.08

The objectives of the FACS trial are to determine: (i) Whether initiation of fluvastatin therapy in patients with ACS immediately after hospital admission decreases levels of CRP, IL-6, and pregnancy-associated plasma protein A/ proform eosinophilic major basic protein (PAPP-A/proMBP), which represent indirect markers of plaque instability and indicators of poor prognosis; and (ii) Whether initiation of fluvastatin therapy decreases the occurrence of ischemic events (death, nonfatal myocardial infarction, recurrent symptomatic ischemia, urgent revascularization, cardiac arrest) in patients with ACS.

Negative_regulation (decreases) of PAPP-A in plasma associated with rhinitis, acute coronary syndrome, ischemia, myocardial infarction and death

12) Confidence 0.18 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC555952 Disease Relevance 1.16 Pain Relevance 0.12

Newborns and young infants less than 4–6 months of age also have increased free fraction of the drug in the blood because of decreased plasma protein (less alpha-1 acid glycoprotein and albumin) binding.

Negative_regulation (decreased) of plasma protein in plasma

13) Confidence 0.01 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.47 Pain Relevance 1.47

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