INT249049

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 24.77
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ARID1B) nucleus (ARID1B) intracellular (ARID1B)
DNA binding (ARID1B)
Anatomy Link Frequency
body 3
coronary artery 1
endothelial cells 1
fat 1
sympathetic 1
ARID1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 96.56 Very High Very High Very High
tolerance 8 93.76 High High
cytokine 6 82.28 Quite High
Clonidine 5 77.04 Quite High
depression 11 71.20 Quite High
alcohol 38 63.72 Quite High
antagonist 16 61.32 Quite High
Etanercept 5 60.52 Quite High
Neuropeptide y 12 59.20 Quite High
Inflammatory response 1 52.80 Quite High
Disease Link Frequency Relevance Heat
Obstructive Sleep Apnea 815 100.00 Very High Very High Very High
Apnoea 611 100.00 Very High Very High Very High
Adhesions 5 100.00 Very High Very High Very High
Body Weight 17 99.98 Very High Very High Very High
Hyperglycemia 16 99.98 Very High Very High Very High
Diabetes Mellitus 82 99.88 Very High Very High Very High
Obesity 269 99.28 Very High Very High Very High
Overweight 15 99.10 Very High Very High Very High
Metabolic Syndrome 240 99.00 Very High Very High Very High
Increased Venous Pressure Under Development 30 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data suggest that increased OSA severity may be associated with decreased physical activity.
Positive_regulation (increased) of OSA associated with apnoea
1) Confidence 0.56 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 1.01 Pain Relevance 0
Among men with MS, free from comorbidities, who report symptoms suggestive of sleep-disordered breathing, high serum glucose is associated with a significant increase in the frequency of OSA, even after adjustment for BMI.
Positive_regulation (increase) of OSA associated with apnoea, obesity and metabolic syndrome
2) Confidence 0.56 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.28 Pain Relevance 0
Between subjects with MS, elevated serum glucose levels indicate a higher probability for the presence of OSA.



Positive_regulation (probability) of OSA associated with apnoea and metabolic syndrome
3) Confidence 0.40 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2868349 Disease Relevance 1.57 Pain Relevance 0
Although premenopausal women have a decreased risk for OSA, the risk of OSA increases in both men and women as they age.
Positive_regulation (increases) of OSA associated with apnoea
4) Confidence 0.38 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 0.90 Pain Relevance 0
We found that increased OSA severity was associated with decreased objectively measured physical activity while controlling for age, gender, and daytime sleepiness (Table 3).
Positive_regulation (increased) of OSA associated with apnoea and sleep disorders
5) Confidence 0.38 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 0.81 Pain Relevance 0
Findings from several studies using subjective measures of activity indicate that increased OSA severity is associated with decreased physical activity [13, 14].
Positive_regulation (increased) of OSA associated with apnoea
6) Confidence 0.38 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 1.27 Pain Relevance 0.03
The increased prevalence of persons in the USA who are overweight or obese has been accompanied by a parallel increase in the prevalence of obstructive sleep apnea (OSA) [1].
Positive_regulation (increase) of OSA associated with apnoea, obesity and overweight
7) Confidence 0.38 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 1.44 Pain Relevance 0.04
Arguably, it appears useful for the clinician treating men with diagnosed MS to bear in mind that they may have some reduction of sleep quality and that hyperglycemia increases the likelihood of overt OSA.
Positive_regulation (increases) of OSA associated with hyperglycemia, apnoea and metabolic syndrome
8) Confidence 0.38 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.40 Pain Relevance 0
Cross-sectional data from the Wisconsin Sleep Cohort Study (1387 participants) has shown a greater prevalence of diabetes with increasing severity of OSA (Reichmuth et al 2005).
Positive_regulation (increasing) of OSA associated with diabetes mellitus and obstructive sleep apnea
9) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.52 Pain Relevance 0.04
D-dimer, a degradation product of fibrin, is elevated in OSA indicating increased fibrinolytic activity with higher levels seen in patients with greater hypoxia (Shitrit et al 2005).
Positive_regulation (elevated) of OSA associated with hypoxia and obstructive sleep apnea
10) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.15 Pain Relevance 0.09
OSA is associated with increased reactive oxygen species production in some leukocyte populations and increased adhesion molecules expression and increased monocyte adherence to human endothelial cells in vitro with reductions by treatment with CPAP (Dyugovskaya et al 2002; El-Solh et al 2002).
Positive_regulation (increased) of OSA in endothelial cells associated with obstructive sleep apnea and adhesions
11) Confidence 0.19 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.86 Pain Relevance 0.05
Numerous studies have demonstrated an increased prevalence of OSA at the time of diagnosis of coronary artery disease (Mooe et al 1996; Peker et al 1999) but these studies demonstrate the association between OSA and coronary artery disease at the point of time of a cardiac event rather than in the years leading up to the event when the coronary artery disease was developing.
Positive_regulation (prevalence) of OSA in coronary artery associated with coronary artery disease and obstructive sleep apnea
12) Confidence 0.19 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.59 Pain Relevance 0.03
Drug treatment of OSA
Positive_regulation (treatment) of OSA associated with obstructive sleep apnea
13) Confidence 0.19 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.57 Pain Relevance 0.10
Yet to date, there is no prospective study that has explored a possible role of an OSA triggered NF-kappaB-mediated TNF-?
Spec (possible) Positive_regulation (triggered) of OSA associated with apnoea
14) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.71 Pain Relevance 0.16
However, other studies have failed to show significant relationship between GERD and OSA.27,28 Moreover, in a recent study applying simultaneous recordings of high resolution manometry (impedance and pH monitoring) and polysomnography, the pressure of the upper esophageal sphincter and esophago-gastric junction increased during OSA despite decreased esophageal body pressure, and the incidence of GERD was not different from controls.29 Although the relationship between OSA and GERD is not clear, treatment of OSA has been shown to improve GERD30 and continuous positive airway pressure (CPAP) has been demonstrated to reduce the total 24 hour esophageal acid contact time.31,32


Positive_regulation (increased) of OSA in body associated with apnoea and gastroesophageal reflux disease
15) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879818 Disease Relevance 1.81 Pain Relevance 0
We found that leptin levels are clearly elevated in OSA patients (mean basal value = 12.1 ± 12.2 ug/L; men normal range: 3.8 ± 1.8 ug/L) but these levels do not correlate with OSA severity when considering confounders as obesity and fat distribution.
Positive_regulation (elevated) of OSA in fat associated with apnoea and obesity
16) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.15 Pain Relevance 0
In alternative, OSA may be a cause of elevated leptin serum levels through the effects of hypoxemia, sleep fragmentation or heightened sympathetic activity.
Positive_regulation (elevated) of OSA in sympathetic associated with apnoea
17) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.22 Pain Relevance 0
Under experimental conditions, intermittent hypoxia stimulates leptin production and a number of studies have demonstrated that serum leptin levels are elevated in OSA patients, independently of obesity [18,26-32] despite some couldn't find that relationship when controlled for body fat [12,33,34].
Positive_regulation (elevated) of OSA in body associated with apnoea, hypoxia and obesity
18) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.18 Pain Relevance 0.08
It is known that every 10-Kg increment in body weight increases OSA risk twofold [8].
Positive_regulation (increases) of OSA in body associated with apnoea and body weight
19) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.11 Pain Relevance 0.08

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