INT24905

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Context Info
Confidence 0.39
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
SW-480 2
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 100.00 Very High Very High Very High
COX-2 inhibitor 3 93.68 High High
Morphine 2 75.20 Quite High
cINOD 1 73.96 Quite High
COX2 2 66.72 Quite High
abdominal pain 2 59.80 Quite High
addiction 1 25.00 Low Low
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 5 99.54 Very High Very High Very High
Reprotox - General 1 5 97.04 Very High Very High Very High
Colon Cancer 6 93.44 High High
Immunodeficiency 3 92.64 High High
Syndrome 2 78.12 Quite High
Oligohydramnios 1 77.16 Quite High
Repression 2 75.00 Quite High
INFLAMMATION 1 73.72 Quite High
Hypopituitarism 11 72.24 Quite High
Cataract 4 61.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, it was demonstrated that SIV (SIVmac239) infection may result in gradual reduction of the MOR gene expression and Sp1 during a period of 48 h postinfection by analysis of quantitative real-time RT-PCR and Western blotting.
Negative_regulation (reduction) of Gene_expression (expression) of Sp1 associated with mu opioid receptor and infection
1) Confidence 0.39 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.71 Pain Relevance 0.36
All of them had depressed hCG, SP1 and PAPP-A levels.
Negative_regulation (depressed) of Gene_expression (levels) of SP1
2) Confidence 0.35 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.50 Pain Relevance 0.06
Treatment of SW-480 cells with Cel, NM, and NS also decreased Sp1 and Sp4 protein expression but not that of Sp2 or Sp3.
Negative_regulation (decreased) of Gene_expression (expression) of Sp1 in SW-480
3) Confidence 0.11 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.48 Pain Relevance 0.23
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Negative_regulation (Measured) of Gene_expression (fractions) of Specificity protein 1
4) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0

General Comments

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