INT24907

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 28.32
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)
Anatomy Link Frequency
plaques 5
plasma 4
chest 2
coronary artery 1
shoulder 1
PAPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 19 99.18 Very High Very High Very High
Angina 192 99.16 Very High Very High Very High
Inflammation 207 98.80 Very High Very High Very High
tolerance 3 98.48 Very High Very High Very High
diclofenac 53 97.88 Very High Very High Very High
beta blocker 4 96.44 Very High Very High Very High
metalloproteinase 37 93.88 High High
aspirin 4 92.28 High High
ischemia 113 89.76 High High
Inflammatory marker 38 82.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 14 100.00 Very High Very High Very High
Rhinitis 4 100.00 Very High Very High Very High
Acute Coronary Syndrome 449 99.84 Very High Very High Very High
Ectopic Pregnancy 855 99.80 Very High Very High Very High
Death 93 99.18 Very High Very High Very High
Abdominal Pain 19 99.18 Very High Very High Very High
Cv General 3 Under Development 69 99.16 Very High Very High Very High
Coronary Artery Disease 132 98.96 Very High Very High Very High
Atherosclerotic Plaque 40 98.94 Very High Very High Very High
Reprotox - General 1 133 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: PAPP-A was abundantly expressed in plaque cells and extracellular matrix of ruptured and eroded unstable plaques, but not in stable plaques.
Gene_expression (expressed) of PAPP-A in plaques
1) Confidence 0.75 Published 2001 Journal N. Engl. J. Med. Section Body Doc Link 11586954 Disease Relevance 0.08 Pain Relevance 0
Levels of PAPP-A were significantly higher in the UA and AMI groups than in the SA and control groups.
Gene_expression (Levels) of PAPP-A associated with angina and myocardial infarction
2) Confidence 0.75 Published 2010 Journal J. Int. Med. Res. Section Abstract Doc Link 20515576 Disease Relevance 2.06 Pain Relevance 1.04
The primary endpoint relates to levels of CRP, IL-6, and PAPP-A/proMBP.
Gene_expression (levels) of PAPP-A
3) Confidence 0.75 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC555952 Disease Relevance 1.29 Pain Relevance 0.20
Levels of PAPP-A were similar in the SA and control groups, and higher in the ACS patients who were cardiac troponin T-negative (comprising UA and AMI patients) than in the control and SA groups.
Gene_expression (Levels) of PAPP-A associated with acute coronary syndrome, angina and myocardial infarction
4) Confidence 0.75 Published 2010 Journal J. Int. Med. Res. Section Abstract Doc Link 20515576 Disease Relevance 2.12 Pain Relevance 1.11
The authors indicated that clinical evidence of EP (vaginal bleeding, abdominal pain) and severely decreased or absent serum PAPP-A levels in women with a positive pregnancy test suggest a diagnosis of EP as the main possibility.
Neg (absent) Gene_expression (levels) of PAPP-A associated with abdominal pain, ectopic pregnancy and reprotox - general 1
5) Confidence 0.75 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.14 Pain Relevance 0.10
PAPP-A could not be detected in any of the decidualized endometrial tissues studied using immunohistochemical techniques.36
Neg (not) Gene_expression (detected) of PAPP-A
6) Confidence 0.75 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.78 Pain Relevance 0
Indications for both parallel as well as divergence in the expression of PAPP-A and troponin-T was also evident when serial timed samples available from a number of patients were analyzed.
Gene_expression (expression) of PAPP-A
7) Confidence 0.75 Published 2002 Journal Clin. Biochem. Section Body Doc Link 12493581 Disease Relevance 0.07 Pain Relevance 0
Serum PAPP-A, progesterone, LIF, HPL, and glycodelin levels did not significantly differ between the two groups.
Gene_expression (levels) of PAPP-A
8) Confidence 0.75 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.43 Pain Relevance 0.03
The levels of PAPP-A/proMBP were determined by Kryptor system (Brahms, Germany).


Gene_expression (levels) of PAPP-A
9) Confidence 0.75 Published 2010 Journal Trials Section Body Doc Link PMC2886041 Disease Relevance 0 Pain Relevance 0
Bayes-Genis et al. found abundant PAPP-A expression in unstable plaques but not in stable plaques from patients died of sudden cardiac death, mostly in the inflammatory shoulder region.
Gene_expression (expression) of PAPP-A in shoulder associated with inflammation and myocardial infarction
10) Confidence 0.75 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.79 Pain Relevance 0.13
However, our present understanding of the regulation of PAPP-A production is incomplete.
Gene_expression (production) of PAPP-A
11) Confidence 0.75 Published 1994 Journal Biol. Reprod. Section Abstract Doc Link 7511420 Disease Relevance 0 Pain Relevance 0
The co-primary endoints were the levels of CRP, IL-6, and PAPP-A/proMBP at days 2 and 30.
Gene_expression (levels) of PAPP-A
12) Confidence 0.75 Published 2010 Journal Trials Section Body Doc Link PMC2886041 Disease Relevance 0.90 Pain Relevance 0.23
Levels of PAPP-A in ACS patients were positively correlated with levels of hs-CRP and TNF-alpha.
Gene_expression (Levels) of PAPP-A associated with acute coronary syndrome
13) Confidence 0.75 Published 2010 Journal J. Int. Med. Res. Section Abstract Doc Link 20515576 Disease Relevance 1.97 Pain Relevance 1.05
METHODS: We examined the level of expression of PAPP-A in eight culprit unstable coronary plaques and four stable plaques from eight patients who had died suddenly of cardiac causes.
Gene_expression (expression) of PAPP-A in plaques
14) Confidence 0.75 Published 2001 Journal N. Engl. J. Med. Section Body Doc Link 11586954 Disease Relevance 0.10 Pain Relevance 0
It is difficult to measure PAPP-A present in atherosclerotic plaques by immunoassays because they are designed to detect PAPP-A present in pregnancy sera.
Gene_expression (present) of PAPP-A in plaques associated with atherosclerotic plaque
15) Confidence 0.65 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.59 Pain Relevance 0.07
Although PAPP-A, maternal serum CK, and CA 125 concentrations were shown to be helpful for EP differential diagnosis, they do not represent methods of choice.
Gene_expression (helpful) of PAPP-A associated with ectopic pregnancy
16) Confidence 0.65 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.75 Pain Relevance 0
Serum PAPP-A levels were lower in the EP and intrauterine abortion groups compared to the normal pregnancy group; they were undetectable in 82% of the EP group and 55% of the intrauterine abortion group.
Gene_expression (levels) of PAPP-A associated with ectopic pregnancy and reprotox - general 1
17) Confidence 0.65 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.50 Pain Relevance 0.08
Our observation that PAPP-A levels were not influenced by fluvastatin therapy is in agreement with the literary data, showing no [22] or only mild [23] effect of statins on PAPP-A.
Gene_expression (levels) of PAPP-A
18) Confidence 0.65 Published 2010 Journal Trials Section Body Doc Link PMC2886041 Disease Relevance 0.94 Pain Relevance 0.23
PAPP-A blood levels seem to be an independent predictor of ischemic cardiac events and indicative of revascularization in patients with suspected MI but negative troponin: Lund J et al. found that PAPP-A plasma levels >2.9 mUI/l were associated with a risk of MI, death or revascularization 4.6-fold higher vs PAPP-A plasma levels <2.9 mUI/l (Lund J et al. 2003).
Gene_expression (levels) of PAPP-A in blood associated with death
19) Confidence 0.65 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.78 Pain Relevance 0.12
Sjöberg35 measured serum PAPP-A concentrations in 164 patients presented to gynecologic emergency services: 124 women had EP and 40 had intrauterine abortions.
Gene_expression (concentrations) of PAPP-A associated with emergencies and ectopic pregnancy
20) Confidence 0.65 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.29 Pain Relevance 0.09

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