INT249123

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 0.57
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
hypothalamus 1
synapses 1
hippocampus 1
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 10 99.06 Very High Very High Very High
Hippocampus 77 99.04 Very High Very High Very High
long-term potentiation 39 96.84 Very High Very High Very High
agonist 52 86.48 High High
Dopamine 52 86.16 High High
antagonist 26 67.68 Quite High
dopamine receptor 40 66.44 Quite High
Glutamate receptor 9 12.32 Low Low
Glutamate 2 9.20 Low Low
corticosteroid 37 7.04 Low Low
Disease Link Frequency Relevance Heat
Hypoxia 7 78.96 Quite High
Obesity 78 73.32 Quite High
Disease Progression 12 65.84 Quite High
Anxiety Disorder 6 60.16 Quite High
Sprains And Strains 2 52.08 Quite High
Organ Transplantation 7 51.04 Quite High
Renal Cancer 54 50.00 Quite Low
Cancer 20 45.44 Quite Low
Disease 49 42.24 Quite Low
Autoimmune Disease 1 40.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is mainly due to the fact that for rapamycin to be active biologically, it must form a ternary complex with mTOR and FKBP12 (FK506-binding protein 12 kDa), a small cytosolic protein receptor.
mTOR Binding (complex) of
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
This is mainly due to the fact that for rapamycin to be active biologically, it must form a ternary complex with mTOR and FKBP12 (FK506-binding protein 12 kDa), a small cytosolic protein receptor.
rapamycin Binding (complex) of
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
rapamycin Binding (associated) of in hippocampus associated with hippocampus
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.06 Pain Relevance 0.05
Intracerebroventricular leptin reduces food intake by modulating AMPK-mTOR hypothalamic phosphorylation levels to a greater extent in exercised animals
mTOR Binding (hypothalamic) of associated with intracerebroventricular
4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.05
Furthermore, these findings provide support to the hypothesis that AMPK and mTOR interact in the hypothalamus to control feeding in exercised rats, in an IL-6-dependent manner.


mTOR Binding (interact) of in hypothalamus
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0
In hippocampal neurons, for example, an interaction of ERK and mTOR in increasing the translational capacity has recently been demonstrated after LTP-inducing stimulation and activation of neuromodulatory transmitter receptors (Gelinas et al. 2007; Tsokas et al. 2007), and a dopaminergic stimulation of rapamycin-sensitive local protein synthesis has been implicated in the activation of previously silent synapses (Smith et al. 2005).
mTOR Binding (interaction) of in synapses associated with long-term potentiation
6) Confidence 0.20 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.08
When applied shortly after conditioning, that is, 1 day after SKF-38393 injections, the general protein synthesis blocker anisomycin (not rapamycin, which interferes only with the mTOR-controlled subset of translation) abolished this increment.
mTOR Binding (interferes) of
7) Confidence 0.15 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.12
Of these, the everolimus – bevacizumab combination is the only one where both drugs are tolerated at full dose,82 has promising activity,83 and has now reached randomized phase II testing compared to the established IFN-bevacizumab regimen in the first-line setting (RECORD-2 study).84 Agents that block mTOR complex 2 or the S6K feedback loop (Figure 3) would be of special interest.26
mTOR Binding (complex) of
8) Confidence 0.11 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.07 Pain Relevance 0
Rapamycin binds with high affinity (Kd ?
Rapamycin Binding (binds) of
9) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.13 Pain Relevance 0
Sirolimus which also binds to the FKBP family, particularly FKBP-12, does not bind to calcineurin but instead binds to target molecules with kinase activity called MTOR (mammalian targets of rapamycin), also known as FRAP and RAFT.
MTOR Binding (binds) of
10) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.05 Pain Relevance 0

General Comments

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