INT249133

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Was) protein complex assembly (Was) cytoplasm (Was)
Anatomy Link Frequency
thymocytes 2
germ line 1
Was (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wiskott-aldrich Syndrome 108 97.78 Very High Very High Very High
Disease 56 88.52 High High
Epstein-barr Virus 4 49.12 Quite Low
Apoptosis 4 8.00 Low Low
Immunodeficiency 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Eczema 8 5.00 Very Low Very Low Very Low
Thrombocytopenia 8 5.00 Very Low Very Low Very Low
Hemorrhage 8 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VCA with N-WASP, a protein that otherwise partially compensates for WASP absence in developing thymocytes.



Negative_regulation (absence) of WASP in thymocytes
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2567846 Disease Relevance 0 Pain Relevance 0
VCA) confers an extreme disadvantage in early developing thymocytes, above and beyond the known cost of absence of full-length WASP, and that the disadvantage likely occurs through dominant negative competition of WASP?
Negative_regulation (competition) of WASP in thymocytes
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2567846 Disease Relevance 0.05 Pain Relevance 0
We propose that the multiplicity and diversity of their somatic alleles relative to other WAS germ line alleles is due to a deleterious effect of the presence of truncated WASP over and above the cost of absence of full-length WASP.


Negative_regulation (absence) of WASP in germ line associated with wiskott-aldrich syndrome
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.19 Pain Relevance 0
Western blots showed time-dependent increase of full-length (63 kDa) WASP concurrent with time-dependent decrease of the 47 kDa apparent truncated WASP protein (Figure 4C).
Negative_regulation (decrease) of WASP
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0 Pain Relevance 0

General Comments

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