INT249151

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

cytoskeleton (Cfl1, Was) cytoplasm (Cfl1, Was) plasma membrane (Cfl1) nucleus (Cfl1) intracellular (Cfl1) protein complex assembly (Was)

Anatomy Link Frequency synapse 1 Cfl1 (Mus musculus) Was (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 1 5.00 tolerance 1 5.00 adenocard 1 5.00 cva 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Disease 14 63.76 Wiskott-aldrich Syndrome 27 48.96 Thrombocytopenia 2 35.20 Hemorrhage 2 34.24 Immunodeficiency 3 33.08 Cancer 3 5.00 Eczema 2 5.00 Severe Combined Immunodeficiency 2 5.00 Uveitis 1 5.00 Immune System Diseases 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At the immune synapse, activating mediators such as the lipid phosphoinositol 4,5-biphosphate (PIP2) and cdc42, a GTPase, bind to WASP, releasing autoinhibition and unmasking WASP's C-terminal VCA (verprolin homology, cofilin homology, acidic) domains.

cofilin Binding (bind) of WASP in synapse

1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.