INT249151

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cfl1, Was) cytoplasm (Cfl1, Was) plasma membrane (Cfl1)
nucleus (Cfl1) intracellular (Cfl1) protein complex assembly (Was)
Anatomy Link Frequency
synapse 1
Cfl1 (Mus musculus)
Was (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 63.76 Quite High
Wiskott-aldrich Syndrome 27 48.96 Quite Low
Thrombocytopenia 2 35.20 Quite Low
Hemorrhage 2 34.24 Quite Low
Immunodeficiency 3 33.08 Quite Low
Cancer 3 5.00 Very Low Very Low Very Low
Eczema 2 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 2 5.00 Very Low Very Low Very Low
Uveitis 1 5.00 Very Low Very Low Very Low
Immune System Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the immune synapse, activating mediators such as the lipid phosphoinositol 4,5-biphosphate (PIP2) and cdc42, a GTPase, bind to WASP, releasing autoinhibition and unmasking WASP's C-terminal VCA (verprolin homology, cofilin homology, acidic) domains.
cofilin Binding (bind) of WASP in synapse
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.

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