INT249159

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSPG2, ITPR3) nucleoplasm (ITPR3) endoplasmic reticulum (ITPR3)
extracellular matrix organization (HSPG2) transmembrane transport (ITPR3) cytoplasm (ITPR3)
HSPG2 (Homo sapiens)
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 32.52 Quite Low
qutenza 1 26.84 Quite Low
nociceptor 3 23.36 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
TRP channel 7 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Mechanosensation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 59.68 Quite High
Pain 2 32.52 Quite Low
Nociception 1 11.88 Low Low
Sprains And Strains 9 7.44 Low Low
Arterial-venous Cerebral Malformations 1 6.12 Low Low
Helminth Infection 14 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Neutrophil Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For some of these functions, we have some insights into the nature of events upstream of itr-1 and in particular into the member(s) of the phospholipase C (PLC) family responsible for IP3 production (Figure 1A).
PLC Positive_regulation (responsible) of Gene_expression (production) of IP3
1) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.06 Pain Relevance 0
Exact mechanisms linking PIP3 formation to Ca2+ signals are not yet known, but PIP3 may activate a PLC isoform triggering InsP3 production [118].
PLC Positive_regulation (triggering) of Gene_expression (production) of InsP3
2) Confidence 0.00 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

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