INT249169

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleus (PMAIP1, PRKDC) nucleoplasm (PRKDC) mitochondrion (PMAIP1) enzyme binding (PRKDC) DNA binding (PRKDC) cytosol (PMAIP1)

PMAIP1 (Homo sapiens) PRKDC (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 4 20.56 Inflammation 8 5.00 addiction 3 5.00 TRP channel 2 5.00 Inflammatory response 2 5.00 antagonist 2 5.00 cytokine 1 5.00 cINOD 1 5.00 fibrosis 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 13.60 INFLAMMATION 11 5.00 Adhesions 5 5.00 Disease 5 5.00 Pulmonary Disease 2 5.00 Neutrophil Disorders 2 5.00 Stress 2 5.00 Respiratory Syncytial Virus 1 5.00 Toxicity 1 5.00 Prostate Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conventional and novel PKCs are directly activated by phorbol esters (PMA), potent activators of NADPH oxidase acting as analogs of diacylglycerol, and atypical isoforms are insensitive to PMA [120121122123].

PMA Positive_regulation (activated) of PKCs

1) Confidence 0.00 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.