INT249244

Context Info Confidence 0.24 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

endoplasmic reticulum (STIM1) plasma membrane (STIM1) cytoskeleton (STIM1) cytoplasm (STIM1)

Anatomy Link Frequency pore 1 STIM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 16 5.00 agonist 8 5.00 addiction 6 5.00 TRP channel 4 5.00 Inflammatory response 4 5.00 antagonist 4 5.00 cytokine 2 5.00 cINOD 2 5.00 fibrosis 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 22 5.00 Adhesions 10 5.00 Disease 10 5.00 Targeted Disruption 6 5.00 Pulmonary Disease 4 5.00 Neutrophil Disorders 4 5.00 Stress 4 5.00 Respiratory Syncytial Virus 2 5.00 Toxicity 2 5.00 Prostate Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Experiments of Orai1 and STIM1 overexpression [747576] provided some evidences for the interaction of STIM1, anchored within ER membranes, with Orai1 after intracellular Ca2+ store depletion.

STIM1 Binding (interaction) of

1) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

Recent studies provided evidence for the formation of a ternary complex among TRPC, Orai1, and STIM1 (Fig. 2), in which TRPC is the pore-forming component of SOCs and Orai1, the regulatory subunit that confers store depletion sensitivity to TRPC [77, 79].

STIM1 Binding (complex) of in pore

2) Confidence 0.19 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.