INT249244
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Experiments of Orai1 and STIM1 overexpression [747576] provided some evidences for the interaction of STIM1, anchored within ER membranes, with Orai1 after intracellular Ca2+ store depletion. | |||||||||||||||
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Recent studies provided evidence for the formation of a ternary complex among TRPC, Orai1, and STIM1 (Fig. 2), in which TRPC is the pore-forming component of SOCs and Orai1, the regulatory subunit that confers store depletion sensitivity to TRPC [77, 79]. | |||||||||||||||
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General Comments
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