INT249244

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (STIM1) plasma membrane (STIM1) cytoskeleton (STIM1)
cytoplasm (STIM1)
Anatomy Link Frequency
pore 1
STIM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
TRP channel 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Adhesions 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Neutrophil Disorders 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Respiratory Syncytial Virus 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Prostate Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments of Orai1 and STIM1 overexpression [747576] provided some evidences for the interaction of STIM1, anchored within ER membranes, with Orai1 after intracellular Ca2+ store depletion.
STIM1 Binding (interaction) of
1) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Recent studies provided evidence for the formation of a ternary complex among TRPC, Orai1, and STIM1 (Fig. 2), in which TRPC is the pore-forming component of SOCs and Orai1, the regulatory subunit that confers store depletion sensitivity to TRPC [77, 79].
STIM1 Binding (complex) of in pore
2) Confidence 0.19 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

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