INT249250

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.14
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NCF1) cytosol (NCF1) GTPase activity (NCF1)
cytoplasm (NCF1)
NCF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 90.56 High High
Inflammatory mediators 5 35.88 Quite Low
Inflammation 40 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
TRP channel 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 79.00 Quite High
INFLAMMATION 55 35.48 Quite Low
Adhesions 25 5.00 Very Low Very Low Very Low
Disease 25 5.00 Very Low Very Low Very Low
Pulmonary Disease 10 5.00 Very Low Very Low Very Low
Neutrophil Disorders 10 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Respiratory Syncytial Virus 5 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Prostate Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, downstream effects of conventional, Ca2+-activated PKCs include a direct phosphorylation of p47phox, which leads to membrane translocation of cytosolic components (Fig. 1).


Phosphorylation (phosphorylation) of p47phox
1) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.06 Pain Relevance 0.07
Changes in PLC, PLD, PLA2, and phosphoinositide 3-hydroxykinase activity, protein phosphorylation, modulation of the expression of chemotactic peptide receptors, sequential phosphorylation of p47phox and p67phox, and assembly of the NADPH oxidase in lipid rafts (reviewed by Sheppard et al. [26]) also seem to be implicated in the “priming” phenomenon.
Phosphorylation (phosphorylation) of p47phox
2) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
For example, [Ca2+]c elevation and phosphorylation of p47phox by different protein kinases (PKC, MAPK, PKA, p21-activated kinase) allowing conformational changes of p47phox may promote oxidase activation in response to GM-CSF [25].
Phosphorylation (phosphorylation) of p47phox
3) Confidence 0.19 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
antisense inhibits phosphorylation and translocation of p47phox induced by fMLF, providing evidence for the involvement of PKC?
Phosphorylation (phosphorylation) of p47phox
4) Confidence 0.19 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.08 Pain Relevance 0.07
Changes in PLC, PLD, PLA2, and phosphoinositide 3-hydroxykinase activity, protein phosphorylation, modulation of the expression of chemotactic peptide receptors, sequential phosphorylation of p47phox and p67phox, and assembly of the NADPH oxidase in lipid rafts (reviewed by Sheppard et al. [26]) also seem to be implicated in the “priming” phenomenon.
Phosphorylation (phosphorylation) of p47phox
5) Confidence 0.19 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

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