INT24926

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 10.41
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
granulocyte 3
macrophages 1
THP-1 1
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 18 96.88 Very High Very High Very High
Inflammatory response 84 96.80 Very High Very High Very High
cytokine 64 95.56 Very High Very High Very High
cINOD 17 95.28 Very High Very High Very High
chemokine 23 92.40 High High
anesthesia 3 89.36 High High
Spinal cord 28 89.28 High High
Inflammation 108 87.12 High High
Arthritis 35 74.88 Quite High
Potency 3 64.20 Quite High
Disease Link Frequency Relevance Heat
Injury 9 100.00 Very High Very High Very High
Burns 8 100.00 Very High Very High Very High
Leukemia 7 99.84 Very High Very High Very High
Disorders Of Creatine Metabolism 10 99.58 Very High Very High Very High
Wound Healing 4 99.40 Very High Very High Very High
Infection 19 99.28 Very High Very High Very High
Chronic Lymphoid Leukemia 1 99.00 Very High Very High Very High
Stroke 4 98.92 Very High Very High Very High
Motor Neuron Diseases 36 98.60 Very High Very High Very High
Targeted Disruption 46 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A new discovery of this study is the finding that antagonism of miR-155 by LNA-antimiR leads to down-regulation of the G-CSF mRNA in vitro and in vivo.
Regulation (regulation) of G-CSF
1) Confidence 0.52 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.82 Pain Relevance 0.30
Figure 5.Antagonism of miR-155 leads to down-regulation of the granulocyte colony-stimulating factor (G-CSF).
Regulation (regulation) of G-CSF in granulocyte
2) Confidence 0.52 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0.06
miR-155 mediates regulation of G-CSF
Regulation (regulation) of G-CSF
3) Confidence 0.52 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.10 Pain Relevance 0.09
Figure 5.Antagonism of miR-155 leads to down-regulation of the granulocyte colony-stimulating factor (G-CSF).
Regulation (regulation) of granulocyte colony-stimulating factor in granulocyte
4) Confidence 0.52 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0.06
The effects of burn trauma and granulocyte-colony stimulating factor (G-CSF) treatment on wound healing in a surgical incision model were studied.
Regulation (effects) of G-CSF in granulocyte associated with burns, wound healing and injury
5) Confidence 0.45 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15329458 Disease Relevance 0.96 Pain Relevance 0.09
We have undertaken this experiment to better dissect mechanisms responsible for the previously demonstrated beneficial function of G-CSF in the SOD1(G93A) mouse model for ALS.
Regulation (responsible) of G-CSF associated with motor neuron diseases
6) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 1.14 Pain Relevance 0.07
Additionally, we find that antagonism of miR-155 leads to down-regulation of G-CSF, a regulator of granulopoiesis, produced by activated macrophages during acute inflammatory responses.
Regulation (regulation) of G-CSF in macrophages associated with inflammatory response
7) Confidence 0.38 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.59 Pain Relevance 0.28
Interestingly, among the immune response genes induced by LPS treatment, expression of the Csf3 gene encoding G-CSF was significantly down-regulated in LNA-antimiR-treated cells compared to the untreated and LNA controls (P = 0.014 and P = 0.008, respectively, Student's t-test, two-sided), implying that the regulation of G-CSF expression is mediated by miR-155 (Figure 5A, Supplementary table S1).
Regulation (regulated) of Csf3 gene
8) Confidence 0.38 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.07 Pain Relevance 0.08
All donors tolerated G-CSF administration well.
Regulation (tolerated) of G-CSF
9) Confidence 0.32 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.60 Pain Relevance 0.08
However, the effectiveness of the G-CSF treatment on OU and GU healing time and pain severity did not continue during the post-treatment period.
Regulation (effectiveness) of G-CSF
10) Confidence 0.30 Published 2006 Journal J Eur Acad Dermatol Venereol Section Body Doc Link 16922940 Disease Relevance 0.26 Pain Relevance 0
Indeed, G-CSF is currently under clinical investigation in ischemic stroke [19,20], and ALS [21-23].
Spec (investigation) Regulation (under) of G-CSF associated with stroke and motor neuron diseases
11) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.99 Pain Relevance 0.08
Transient transfection of pre-miR-155 into LPS-stimulated THP-1 cells resulted in significant up-regulation of the G-CSF mRNA (P < 0.01, Student's t-test, two-sided), that reverted to control levels upon antagonism of miR-155 by LNA-antimiR (Figure 5B).
Regulation (regulation) of G-CSF in THP-1
12) Confidence 0.23 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0 Pain Relevance 0
Once prospectively validated, such models will be a valuable resource for helping to target G-CSF support.


Regulation (target) of G-CSF
13) Confidence 0.11 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.53 Pain Relevance 0
To determine the final influence of G-CSF on myeloid leukemia, further long-term follow-up studies are needed.
Spec (determine) Regulation (influence) of G-CSF associated with leukemia
14) Confidence 0.11 Published 1989 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 2481758 Disease Relevance 0.70 Pain Relevance 0.09
However, contradictory data exist on the influence of prophylactic G-CSF treatment on the infection rate.
Regulation (influence) of G-CSF associated with infection
15) Confidence 0.04 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020588 Disease Relevance 0.91 Pain Relevance 0.17
DOMS averaged 7.1 +/- 0.3 the day after the race, and 5.0 +/- 0.3, 2.5 +/- 0.2, and 1.6 +/- 0.1 3 days, 5 days, and 7 days post-race, respectively, and each was correlated with CPK (r = .40-.63, P < .001) and changes in IL-6, G-CSF, IL-10, and MCP-1 (r = .28-.77, P < .05).
Regulation (changes) of G-CSF associated with disorders of creatine metabolism
16) Confidence 0.03 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 16061149 Disease Relevance 0.63 Pain Relevance 0.70
On clinical improvement IL-6 serum levels rapidly fell, whereas G-CSF values already slightly elevated before the manifestation of the disease slowly declined.
Regulation (values) of G-CSF associated with disease
17) Confidence 0.03 Published 1993 Journal Br. J. Haematol. Section Abstract Doc Link 7691149 Disease Relevance 0.84 Pain Relevance 0.20
Advanced age may dampen the efficacy of G-CSF to increase EPC number and/or function (Lehrke et al 2006).
Regulation (efficacy) of G-CSF
18) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.50 Pain Relevance 0.11
CPK was correlated with changes in IL-6, G-CSF, IL-10, IL-1ra, and MCP-1 (r = .49-.68), (P < .001), but not IL-8 or MIP-1beta.
Regulation (changes) of G-CSF associated with disorders of creatine metabolism
19) Confidence 0.02 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 16061149 Disease Relevance 0.66 Pain Relevance 0.56

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