INT24930

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Context Info
Confidence 0.26
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.18
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2)
cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
hypothalamus 1
cortex 1
cerebellum 1
hippocampus 1
Adrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 36 99.76 Very High Very High Very High
anesthesia 3 99.60 Very High Very High Very High
Hippocampus 12 98.48 Very High Very High Very High
Clonidine 8 96.64 Very High Very High Very High
antagonist 2 84.96 Quite High
Catecholamine 5 82.44 Quite High
Lasting pain 6 77.76 Quite High
agonist 2 76.08 Quite High
beta blocker 1 49.16 Quite Low
Disease Link Frequency Relevance Heat
Pain 38 99.76 Very High Very High Very High
Shock 16 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 3 81.76 Quite High
Heart Rate Under Development 3 80.08 Quite High
Hypertension 1 70.88 Quite High
Increased Venous Pressure Under Development 1 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADRB2 SNPs rs12654778 and rs1042713 were associated either with CWP alone (p=0.02 for both) or with position along pain spectrum (pain status; p=0.04).
ADRB2 Binding (associated) of associated with pain
1) Confidence 0.26 Published 2010 Journal Pain Section Abstract Doc Link 20167428 Disease Relevance 1.36 Pain Relevance 1.56
Common functional ADRB2 haplotype combinations were also associated with pain status (p(model)=0.002) and, further, with both extent and duration of pain (p(model)=0.003 and p(model)=0.002, respectively).
ADRB2 Binding (associated) of associated with pain
2) Confidence 0.23 Published 2010 Journal Pain Section Abstract Doc Link 20167428 Disease Relevance 1.36 Pain Relevance 1.58
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
beta-adrenoceptor Binding (binding) of in hypothalamus associated with shock, hippocampus and clonidine
3) Confidence 0.20 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.26 Pain Relevance 0.21
Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats.
2-adrenoceptor Binding (interaction) of associated with anesthesia
4) Confidence 0.10 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2481776 Disease Relevance 0.43 Pain Relevance 0.45
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
beta-adrenoceptor Binding (binding) of in hippocampus associated with shock, hippocampus and clonidine
5) Confidence 0.07 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.26 Pain Relevance 0.21
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
beta-adrenoceptor Binding (binding) of in cortex associated with shock, hippocampus and clonidine
6) Confidence 0.07 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.26 Pain Relevance 0.21
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
beta-adrenoceptor Binding (binding) of in cerebellum associated with shock, hippocampus and clonidine
7) Confidence 0.07 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.26 Pain Relevance 0.21

General Comments

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