INT249305

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.62
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Preb) vesicle-mediated transport (Preb) endoplasmic reticulum (Preb)
nucleus (Preb) DNA binding (Preb)
Anatomy Link Frequency
respiratory 2
synapses 1
patterning 1
Preb (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 101 100.00 Very High Very High Very High
depression 88 100.00 Very High Very High Very High
potassium channel 2 99.30 Very High Very High Very High
antagonist 42 98.12 Very High Very High Very High
gABA 41 86.88 High High
Spinal cord 33 74.80 Quite High
GABAergic 9 71.64 Quite High
agonist 25 68.96 Quite High
Neurotransmitter 9 58.16 Quite High
imagery 40 50.40 Quite High
Disease Link Frequency Relevance Heat
Depression 93 100.00 Very High Very High Very High
Congenital Anomalies 1 49.48 Quite Low
Hypoxia 25 44.24 Quite Low
Convulsion 30 37.52 Quite Low
Targeted Disruption 16 10.72 Low Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Wrinkles 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The respiratory rhythm, which persists after blockade of glycine receptors in slice preparations from older animals, is quite labile since additional blockade of calcium-activated potassium channels (BK channels) results in a severe reduction of the preBötC-driven inspiratory activity in the slice preparation [44].
Negative_regulation (reduction) of preB in respiratory associated with potassium channel
1) Confidence 0.39 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691554 Disease Relevance 0 Pain Relevance 0.09
Inspiratory glycinergic inhibition in the preBötC-driven network
Negative_regulation (inhibition) of preB
2) Confidence 0.39 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691554 Disease Relevance 0 Pain Relevance 0.03
The purpose of this study was to examine factors that may contribute to, or interact with, A1R-mediated depression of preBötC rhythmogenesis including effects of A1R activation on synaptic transmission and membrane properties.
Negative_regulation (depression) of preB associated with depression
3) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.10 Pain Relevance 0.30
For instance, in adult cats antagonism of glycine receptors can block preBötC rhythmogenesis, and injection of the GABAA antagonist bicuculline into the preBötC slows respiratory rhythm and induces apneusis [26].
Negative_regulation (block) of preB in respiratory associated with antagonist
4) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.14 Pain Relevance 0.25
A second set of experiments determined whether the post-synaptic effects of GABAAergic transmission integrate with (effectively sum with) the effects of A1R activation to increase the level of network-level depression of preBötC rhythmogenesis in the medullary slice preparation.
Negative_regulation (depression) of preB associated with depression
5) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.16 Pain Relevance 0.19
Activation of A1R depresses preBötC rhythmogenesis similarly in slice and island preparations, the latter representing a condition of reduced synaptic transmission.
Negative_regulation (depresses) of preB
6) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.06 Pain Relevance 0.03
Although GABAAergic and glycinergic transmission affect the patterning and excitability of the respiratory network within in vitro preparations from neonatal mammals, the data presented herein show that the depression of preBötC rhythmogenesis by A1R activation is unaffected by reducing the overall level of synaptic input received by preBötC neurons, or by antagonizing GABAA or GABAA and glycine receptors.
Negative_regulation (depression) of preB in patterning associated with depression
7) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.16 Pain Relevance 0.08
As the overall structure within the brainstem network was not altered (Figure 5d), the loss in the frequency of sPSCs could be interpreted either as a reduced number of excitatory or inhibitory synapses in the brainstem preBötC region or as an impairment of the transmitter release machinery in all synapses.
Negative_regulation (synapses) of preB in synapses associated with medulla
8) Confidence 0.32 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox