INT249309

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.51
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neurons 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 30 98.98 Very High Very High Very High
medulla 70 98.74 Very High Very High Very High
antagonist 46 85.60 High High
agonist 28 80.64 Quite High
depression 85 78.80 Quite High
Neuronal excitability 25 77.48 Quite High
cocaine 42 67.32 Quite High
gABA 30 64.24 Quite High
adenocard 87 60.00 Quite High
Glutamate 5 13.20 Low Low
Disease Link Frequency Relevance Heat
Convulsion 30 87.44 High High
Depression 90 78.80 Quite High
Attention Deficit Hyperactivity Disorder 7 54.16 Quite High
Hypoxia 25 19.32 Low Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Anxiety 3 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In brainstem-spinal cord preparations Herlenius and Lagercrantz found that A1R activation decreased the Vm of expiratory neurons but did not affect Rin or Vm of inspiratory neurons [23].
Neg (not) Regulation (affect) of Gene_expression (activation) of A1R in neurons associated with medulla and spinal cord
1) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0.14
In our study, we have controlled for the mother's and grandmother's genotype in A1R Hz offspring but not for the father's or grandfather's genotype.
Neg (not) Regulation (controlled) of Gene_expression (offspring) of A1R Hz
2) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.05 Pain Relevance 0.06
Effects of A1R manipulation on slice rhythmogenesis during GABAA receptor antagonism
Regulation (Effects) of Gene_expression (manipulation) of A1R
3) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.25
Effects of A1R manipulation on island rhythmogenesis during GABAA receptor antagonism
Regulation (Effects) of Gene_expression (manipulation) of A1R
4) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
Effects of A1R manipulation on slice rhythmogenesis during GABAA and glycine receptor antagonism
Regulation (Effects) of Gene_expression (manipulation) of A1R
5) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.24 Pain Relevance 0.04
Effects of A1R manipulation on island rhythmogenesis during GABAA and glycine receptor antagonism
Regulation (Effects) of Gene_expression (manipulation) of A1R
6) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.07 Pain Relevance 0

General Comments

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