INT249377

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.40
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Vamp2) plasma membrane (Vamp2) protein complex assembly (Vamp2)
Anatomy Link Frequency
cleavage 3
brain 1
vesicles 1
Vamp2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 44 96.56 Very High Very High Very High
Action potential 27 95.32 Very High Very High Very High
Hippocampus 16 95.28 Very High Very High Very High
Spinal cord 138 94.88 High High
Neurotransmitter 46 87.48 High High
GABAergic 45 50.00 Quite Low
anesthesia 1 45.92 Quite Low
Central nervous system 21 41.52 Quite Low
Calcium channel 11 37.76 Quite Low
imagery 7 19.68 Low Low
Disease Link Frequency Relevance Heat
Infection 12 97.72 Very High Very High Very High
Congenital Anomalies 6 88.24 High High
Disease 18 78.00 Quite High
Ganglion Cysts 8 52.32 Quite High
Anaerobic Bacterial Infections 66 50.00 Quite Low
Toxicity 3 42.88 Quite Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Paralysis 21 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Poisoning 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Localization (abundance) of VAMP2 in brain
1) Confidence 0.51 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (mixture) of VAMP-2
2) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.05 Pain Relevance 0
This core heteromeric protein assembly, comprised of the t-SNAREs syntaxin 1, and SNAP-25 situated at the target or plasma membrane and the v-SNARE VAMP-2/synaptobrevin on secreting vesicles, is responsible for membrane fusion that underlies the Ca2+-triggered neuroexocytosis that is required for AP-dependent neurotransmission signaling point-to-point communication between neurons, as well as the regulated secretion from neuroendocrine cells.
Localization (secreting) of VAMP-2 in vesicles associated with action potential
3) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.15
Cleavage of synaptobrevin II is dependent on synaptic vesicle recycling
Localization (Cleavage) of synaptobrevin II in Cleavage
4) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.08 Pain Relevance 0.53
As BoNT/A and BoNT/E cleave SNAP-25 instead of syb II, we were able to inhibit exocytosis in neurons while still monitor the entry of TeNT through cleavage of syb II.
Localization (cleave) of syb II in cleavage
5) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.16
Furthermore, double KO neurons were largely protected from TeNT, as evidenced by the lack of cleavage of syb II; moreover, these neurons could be re-sensitized through infection with viruses that expressed SV2A or B.
Localization (cleavage) of syb II in cleavage associated with infection
6) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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