INT249378

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.27
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Vamp2) plasma membrane (Vamp2) protein complex assembly (Vamp2)
Anatomy Link Frequency
nerve 1
neurons 1
spinal cord neurons 1
vesicle 1
Vamp2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 71 100.00 Very High Very High Very High
Spinal cord 231 98.58 Very High Very High Very High
Action potential 27 95.08 Very High Very High Very High
Neurotransmitter 42 50.00 Quite Low
Inflammation 3 44.32 Quite Low
Calcium channel 5 7.52 Low Low
Central nervous system 32 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 52 95.92 Very High Very High Very High
Creutzfeldt Jakob Disease 12 68.12 Quite High
Lifespan 1 52.56 Quite High
Anaerobic Bacterial Infections 110 50.00 Quite Low
INFLAMMATION 3 44.32 Quite Low
Ganglion Cysts 8 23.12 Low Low
Neurodegenerative Disease 15 14.88 Low Low
Disease Progression 3 10.64 Low Low
Paralysis 35 5.00 Very Low Very Low Very Low
Targeted Disruption 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that tomosyn is phosphorylated by PKA, leading to a decrease in its binding activity for VAMP-2 (Baba et al., 2005).
Negative_regulation (decrease) of VAMP-2
1) Confidence 0.20 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Inhibitory terminals exhibited no significant reduction of syb II immunofluorescence under TTX conditions, but a 53% reduction was observed in neurons that had been depolarized (Figure 2B).
Neg (no) Negative_regulation (reduction) of syb II in neurons associated with tetrodotoxin
2) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.45
We observed that syb II fluorescence was markedly reduced when hippocampal neurons were depolarized with potassium to drive SV recycling (Figure 2A); this occurred at both excitatory and inhibitory nerve terminals (Figure 2B).
Negative_regulation (reduced) of syb II in nerve
3) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.49
A number of proteins associated with the synaptic vesicle membrane were the first to show reduced levels of expression, including VAMP-2 (vesicle-associated membrane protein-2), synaptophysin and the chaperone CSP (cysteine string protein) (Gray et al., 2009), and these proteins were also reduced when compared with the levels of PSD-related proteins.
Negative_regulation (reduced) of VAMP-2 in vesicle
4) Confidence 0.16 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.27 Pain Relevance 0
Syb II immunofluorescence was reduced in excitatory terminals by 39% in the TTX condition and was further reduced by 65% of under depolarizing conditions, as compared to control.
Negative_regulation (reduced) of Syb II associated with tetrodotoxin
5) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.48
Syb II immunofluorescence was reduced in excitatory terminals by 39% in the TTX condition and was further reduced by 65% of under depolarizing conditions, as compared to control.
Negative_regulation (reduced) of Syb II associated with tetrodotoxin
6) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.52
To test the physiological relevance of these observations, we monitored syb II levels in spinal cord neurons (Figure 2C) and observed that under high potassium conditions syb II immunofluorescence was reduced by 50% as compared to control and non-stimulating (i.e.
Negative_regulation (reduced) of syb II in spinal cord neurons associated with spinal cord
7) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.46

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