INT249396

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.23
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Stx1a) vesicle-mediated transport (Stx1a) plasma membrane (Stx1a)
protein binding, bridging (Stx1a) protein complex (Stx1a)
Stx1a (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 171 99.30 Very High Very High Very High
Calcium channel 8 99.20 Very High Very High Very High
GABAergic 45 88.44 High High
Action potential 19 72.64 Quite High
anesthesia 8 35.36 Quite Low
Pyramidal cell 16 5.00 Very Low Very Low Very Low
Hippocampus 11 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
cerebral cortex 8 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 16 78.72 Quite High
Ganglion Cysts 64 77.64 Quite High
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assay for the binding of syntaxin-1 or SNAP-25 to tomosyn
syntaxin-1 Binding (binding) of
1) Confidence 0.15 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Syntaxin-1 or SNAP-25 bound to MBP-tomosyn-?
Syntaxin-1 Binding (bound) of
2) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
It was shown that the VLD interacts with syntaxin-1 in a manner competitive with VAMP-2, forms the tomosyn complex, and down-regulates the formation of the SNARE complex (Fujita et al., 1998; Yokoyama et al., 1999; Hatsuzawa et al., 2003; Pobbati et al., 2004; Sakisaka et al., 2004).
syntaxin-1 Binding (interacts) of
3) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
VAMP-2 did not affect the binding of syntaxin-1 and SNAP-25 to MBP-VLD.
syntaxin-1 Binding (binding) of
4) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Different affinities for SNAP-25 and syntaxin-1 between the N-terminal WD-40 repeat domain and the C-terminal VLD
syntaxin-1 Binding (affinities) of
5) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
We previously showed that tomosyn is directly phosphorylated by cAMP-dependent protein kinase (PKA) and that this reduces its interaction with syntaxin-1 and enhances the formation of the SNARE complex (Baba et al., 2005).
syntaxin-1 Binding (interaction) of
6) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.08 Pain Relevance 0
Syntaxin-1 and SNAP-25 each enhanced the binding of the other to MBP-VLD by threefold, presumably reflecting the formation of a SNARE complex–like structure.
Syntaxin-1 Binding (binding) of
7) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Frgs. 1 and 2, but not Frg. 3, bound syntaxin-1 (Fig. 7 B).
syntaxin-1 Binding (bound) of
8) Confidence 0.14 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.16 Pain Relevance 0.10
In addition to a well-documented role in membrane fusion for neuroexocytosis and neurotransmitter release, the t-SNAREs SNAP-25 and syntaxin 1 also associate with voltage-gated calcium channels (VGCCs) where they are thought to modulate steady-state inactivation of channel opening thereby regulating calcium currents in response to membrane depolarization [see ref. [6] for review].
syntaxin 1 Binding (associate) of associated with neurotransmitter and calcium channel
9) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.32

General Comments

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