INT249415

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) molecular_function (Dcaf12l2)
cellular_component (Dcaf12l2) biological_process (Dcaf12l2) cytoplasm (Snap25)
Snap25 (Mus musculus)
Dcaf12l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 80 78.40 Quite High
Nerve growth factor 4 41.00 Quite Low
anesthesia 4 5.04 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 74.44 Quite High
Ganglion Cysts 32 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that tomosyn catalyzes oligomerization of the SNARE complex upon the direct interactions of the WD-40 repeat domain with SNAP-25 and syntaxin-1.
SNAP-25 Binding (interactions) of WD-40
1) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.04
Different affinities for SNAP-25 and syntaxin-1 between the N-terminal WD-40 repeat domain and the C-terminal VLD
SNAP-25 Binding (affinities) of WD-40
2) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
S5 shows the effect of the PKA-catalyzed phosphorylation of tomosyn on the oligomerization of the SNARE complex and binding of SNAP-25 to the WD-40 repeat domain of tomosyn.


SNAP-25 Binding (binding) of WD-40
3) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
These results are inconsistent with our present finding that the interaction of the N-terminal WD-40 repeat domain of tomosyn with SNAP-25 did not inhibit the formation of the monomeric SNARE complexes.
SNAP-25 Binding (interaction) of WD-40
4) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.07 Pain Relevance 0

General Comments

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