INT249457

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (URI1) protein folding (URI1) nucleus (URI1)
cytoplasm (URI1)
URI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 99.04 Very High Very High Very High
Arthritis 127 96.24 Very High Very High Very High
Pain 30 73.48 Quite High
methotrexate 3 20.92 Low Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
spinal inflammation 7 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 89 96.24 Very High Very High Very High
Arthritis 37 84.40 Quite High
Disease 53 80.20 Quite High
Arthralgia 4 73.48 Quite High
Intellectual Impairment 2 45.76 Quite Low
Mycobacterial Infection 65 5.00 Very Low Very Low Very Low
Pain 26 5.00 Very Low Very Low Very Low
Uveitis 17 5.00 Very Low Very Low Very Low
Death 13 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Where DOIs exist, they are supposed to be the definitive URI.
Positive_regulation (supposed) of URI
1) Confidence 0.27 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2568856 Disease Relevance 0 Pain Relevance 0
Encapsulated INH, SM and RMP showed 4-8 and 22-25-fold increase in the intracellular concentration with respect to the extracellular concentration.
Positive_regulation (increase) of RMP
2) Confidence 0.13 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991688 Disease Relevance 0 Pain Relevance 0
Great financial burden is imposed on families of patients with JIA and may be attributed to the following: expensive biologic agents; frequent subspecialty outpatient visits; periodic laboratory and imaging tests; frequent visits to the pediatrician for increased URI, etc. due to immunosuppression; physical therapy; inpatient infusions and hospitalizations; and missed work days for the parents.
Positive_regulation (increased) of URI associated with imagery and arthritis
3) Confidence 0.08 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2914068 Disease Relevance 0.80 Pain Relevance 0.45

General Comments

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