INT24946

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 16.75
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
cleavage 2
fat 1
pancreas 1
lung 1
PRSS1 (Homo sapiens)
PRSS1 - E79K (2) PRSS1 - R122H (1)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 402 100.00 Very High Very High Very High
fibrosis 72 100.00 Very High Very High Very High
Inflammation 97 99.84 Very High Very High Very High
alcohol 25 98.84 Very High Very High Very High
agonist 53 95.76 Very High Very High Very High
abdominal pain 21 85.24 High High
Bile 18 79.64 Quite High
Pain management 9 78.24 Quite High
cytokine 6 59.92 Quite High
Pain 38 55.68 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 690 100.00 Very High Very High Very High
Cystic Fibrosis 56 100.00 Very High Very High Very High
Pancreatic Cancer 101 99.92 Very High Very High Very High
INFLAMMATION 113 99.84 Very High Very High Very High
Injury 17 99.16 Very High Very High Very High
Lung Cancer 1 98.46 Very High Very High Very High
Disease 118 93.68 High High
Cancer 72 93.20 High High
Metastasis 11 90.72 High High
Apoptosis 56 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obviously, the data basis for the estimation of the pancreatic cancer risk in patients with PRSS1 associated HCP is small.
PRSS1 Binding (associated) of associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.47 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 2.01 Pain Relevance 0.87
The authors conclude, that trypsinogen and cathepsin B could potentially interact.
trypsinogen Binding (interact) of
2) Confidence 0.47 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10
Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).
PRSS1 (E79K) Binding (Interaction) of associated with pancreatitis
3) Confidence 0.37 Published 2004 Journal Hum. Mutat. Section Title Doc Link 14695529 Disease Relevance 0.40 Pain Relevance 0.09
Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).
trypsin (E79K) Binding (Interaction) of associated with pancreatitis
4) Confidence 0.37 Published 2004 Journal Hum. Mutat. Section Title Doc Link 14695529 Disease Relevance 0.40 Pain Relevance 0.09
Obviously, the data basis for the estimation of the pancreatic cancer risk in patients with PRSS1 associated HCP is small.
PRSS1 Binding (associated) of associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.37 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 2.01 Pain Relevance 0.87
Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.
trypsinogen Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
6) Confidence 0.37 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.82 Pain Relevance 1.09
The complex interactions between recurrent trypsin-mediated pancreatic injury, alcohol-associated pancreatic injury and SPINK1 polymorphisms in chronic pancreatitis (CP) are undefined.
trypsin Binding (interactions) of associated with injury, chronic pancreatitis and alcohol
7) Confidence 0.37 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2289874 Disease Relevance 0.69 Pain Relevance 0.39
Individuals with pathogenic cationic trypsinogen mutations were excluded.
cationic trypsinogen Binding (Individuals) of
8) Confidence 0.36 Published 2005 Journal Hum. Mutat. Section Abstract Doc Link 16134171 Disease Relevance 1.44 Pain Relevance 0.79
At the present knowledge it can be only stated that the combined genotype CFTR (F508del)/PRSS1 (S181G) is associated to a mild phenotype of acute recurrent pancreatitis in this child without any further conclusion on its pathogenetic role or prediction on the course of the disease.



PRSS1 Binding (associated) of associated with pancreatitis and disease
9) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2970583 Disease Relevance 0.75 Pain Relevance 0.07
A novel A121T mutation in human cationic trypsinogen associated with hereditary pancreatitis: functional data indicating a loss-of-function mutation influencing the R122 trypsin cleavage site.
cationic trypsinogen Binding (associated) of in cleavage associated with pancreatitis
10) Confidence 0.33 Published 2008 Journal J. Med. Genet. Section Title Doc Link 18511571 Disease Relevance 0.19 Pain Relevance 0.09
Hereditary pancreatitis is an unusual form of acute and chronic pancreatitis that is usually associated with two specific mutations in the cationic trypsinogen gene.
trypsinogen Binding (associated) of associated with pancreatitis and chronic pancreatitis
11) Confidence 0.32 Published 1999 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 10503134 Disease Relevance 0.35 Pain Relevance 0.10
The highest risk is associated with autosomal-dominant mutations (N29I, R122H) of the cationic trypsinogen (PRSS1).
cationic trypsinogen (R122H) Binding (associated) of
12) Confidence 0.26 Published 2003 Journal Dig Dis Section Abstract Doc Link 14752225 Disease Relevance 0.42 Pain Relevance 0.26
The highest risk is associated with autosomal-dominant mutations (N29I, R122H) of the cationic trypsinogen (PRSS1).
PRSS1 Binding (associated) of
13) Confidence 0.26 Published 2003 Journal Dig Dis Section Abstract Doc Link 14752225 Disease Relevance 0.42 Pain Relevance 0.26
C to A mutation occurred in exon 3 of PRSS1, and T to A mutation in the same exon.
PRSS1 Binding (exon) of
14) Confidence 0.24 Published 2008 Journal HBPD INT Section Body Doc Link 18522894 Disease Relevance 0.17 Pain Relevance 0
METHODS: We analyzed 381 patients with a primary diagnosis of chronic or recurrent pancreatitis using the Ambry Test: Pancreatitis to obtain comprehensive genetic information for the CFTR, SPINK1, and PRSS1 genes.
PRSS1 Spec (analyzed) Binding (information) of
15) Confidence 0.22 Published 2006 Journal Pancreas Section Body Doc Link 17003641 Disease Relevance 0.09 Pain Relevance 0
It was presumed from these findings that the increase in kinin and its activation at the acute phase of pancreatitis might be due to kallikrein or trypsin originating from the pancreas.
trypsin Spec (might) Binding (due) of in pancreas associated with pancreatitis
16) Confidence 0.13 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2481954 Disease Relevance 0.61 Pain Relevance 0.17
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
PRSS1 Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
17) Confidence 0.09 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.53 Pain Relevance 0.28
Elemental diets cause less stimulation than standard formulas, because of their low fat content, the presence of free aminoacids instead of intact proteins which bind to free trypsin in the gut, causing trypsin levels to fall, and less acid production from the stomach.

2.3.

trypsin Binding (bind) of in fat
18) Confidence 0.07 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.15 Pain Relevance 0
PSTI, LPL, PRSS1, and CFTR genes presented no association with chronic alcoholic pancreatitis.
PRSS1 Neg (no) Binding (association) of
19) Confidence 0.06 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0.05 Pain Relevance 0
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
trypsin Binding (thrombin) of associated with inflammation
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.68 Pain Relevance 0.24

General Comments

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