INT249465

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) plasma membrane (Slc6a4)
Slc6a4 (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 9 84.20 Quite High
Hippocampus 16 66.32 Quite High
Serotonin 3 50.00 Quite Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
Nucleus accumbens 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 19 84.68 Quite High
Depression 9 84.20 Quite High
Urological Neuroanatomy 6 75.44 Quite High
Hypertension 2 39.28 Quite Low
Targeted Disruption 1 35.12 Quite Low
Stress 3 10.44 Low Low
Shock 1 10.16 Low Low
Affective Disorder 3 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 2 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been previously proposed that 5-HTT-mediated increases in 5-HT-ergic neurotransmission upregulate BDNF expression via increases in cAMP response element binding protein phosphorylation (Duman et al., 1997, 1999; Nibuya et al., 1996), but it has also been demonstrated that male and female mice with partial (5-HTT +/?)
Positive_regulation (increases) of 5-HTT-mediated Positive_regulation (upregulate) of Gene_expression (expression) of BDNF
1) Confidence 0.31 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.30 Pain Relevance 0.08

General Comments

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