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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ephb1, Src) plasma membrane (Ephb1, Src) endosome (Ephb1)
mitochondrion (Src) enzyme binding (Src) response to stress (Src)
Anatomy Link Frequency
neurons 3
Ephb1 (Rattus norvegicus)
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 28 96.00 Very High Very High Very High
Glutamate 3 95.20 Very High Very High Very High
Spinal cord 30 86.92 High High
Hippocampus 5 82.80 Quite High
Thermal hyperalgesia 13 51.52 Quite High
Inflammation 9 50.00 Quite Low
Eae 10 49.04 Quite Low
intrathecal 16 46.92 Quite Low
Neuropathic pain 9 24.92 Low Low
Hyperalgesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 92.44 High High
Targeted Disruption 2 90.96 High High
Hyperalgesia 25 51.52 Quite High
INFLAMMATION 9 50.00 Quite Low
Inflammatory Pain 7 49.04 Quite Low
Neuropathic Pain 18 24.92 Low Low
Nociception 14 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Takasu et al. (2002), working with cultured embryonic cortical neurons, established that EphB receptor activation in these neurons, obtained with treatment with ephrinB2-Fc chimeras, induced Src family kinases phosphorylation at residue Tyr416, with consequent NR2B receptor phosphorylation and increased Ca2+ influx through NMDA receptors upon glutamate administration.
Positive_regulation (activation) of EphB in neurons Positive_regulation (induced) of Phosphorylation (phosphorylation) of Src in neurons associated with glutamate and nmda receptor
1) Confidence 0.22 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.23 Pain Relevance 0.31

General Comments

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