INT249481

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.36
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ephb1, Efnb2) endosome (Ephb1) signal transduction (Ephb1)
cell adhesion (Efnb2) cytoplasm (Ephb1)
Ephb1 (Rattus norvegicus)
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 9 100.00 Very High Very High Very High
Lasting pain 7 98.52 Very High Very High Very High
Inflammation 9 97.64 Very High Very High Very High
Eae 10 92.64 High High
Dorsal horn neuron 6 88.12 High High
Root ganglion neuron 3 87.16 High High
Dorsal horn 11 80.72 Quite High
hyperexcitability 2 78.96 Quite High
wide dynamic range 1 72.16 Quite High
dorsal root ganglion 1 70.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 18 100.00 Very High Very High Very High
Pain 13 98.08 Very High Very High Very High
INFLAMMATION 9 97.64 Very High Very High Very High
Inflammatory Pain 7 92.64 High High
Ganglion Cysts 5 86.84 High High
Nociception 14 86.00 High High
Injury 5 61.84 Quite High
Hyperalgesia 25 60.40 Quite High
Nervous System Injury 3 9.00 Low Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evidence presented here, together with previously reported findings described above (Battaglia et al., 2003; Kobayashi et al., 2007; Song et al., 2008a,b) would suggest that the interaction of presynaptic ephrinB2 (and in neuropathic pain also possibly ephrinB1) with EphB receptors is required for the onset of different forms of persistent pain (both inflammatory and neuropathic).
Positive_regulation (required) of EphB Binding (interaction) of ephrinB2 associated with pain, inflammation, lasting pain and neuropathic pain
1) Confidence 0.03 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.36 Pain Relevance 1.12

General Comments

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