INT249483

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.35
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ephb1, Efnb2) endosome (Ephb1) signal transduction (Ephb1)
cell adhesion (Efnb2) cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 1
Ephb1 (Rattus norvegicus)
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 18 100.00 Very High Very High Very High
Dorsal horn neuron 12 99.84 Very High Very High Very High
Lasting pain 14 97.64 Very High Very High Very High
nociceptor 4 97.36 Very High Very High Very High
Inflammation 18 96.76 Very High Very High Very High
Eae 20 92.64 High High
Root ganglion neuron 6 88.40 High High
Dorsal horn 22 78.96 Quite High
hyperexcitability 4 78.96 Quite High
Pain 12 77.08 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 36 100.00 Very High Very High Very High
Nociception 28 100.00 Very High Very High Very High
Nervous System Injury 6 99.56 Very High Very High Very High
Pain 26 97.20 Very High Very High Very High
INFLAMMATION 18 96.76 Very High Very High Very High
Inflammatory Pain 14 92.64 High High
Ganglion Cysts 10 90.96 High High
Injury 10 87.12 High High
Hyperalgesia 50 64.72 Quite High
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, binding of ephrinB2 on nociceptive neurons to EphB1 in dorsal horn neurons could itself trigger reverse signaling in nociceptors, since ephrinB2 activation can activate intracellular signaling cascades, and in other systems this form of retrograde signaling has been shown to regulate synaptic activity (reviewed in Caló et al., 2006).
EphB1 Binding (binding) of ephrinB2 in neurons associated with nociception, nociceptor and dorsal horn neuron
1) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.99 Pain Relevance 0.57
The evidence presented here, together with previously reported findings described above (Battaglia et al., 2003; Kobayashi et al., 2007; Song et al., 2008a,b) would suggest that the interaction of presynaptic ephrinB2 (and in neuropathic pain also possibly ephrinB1) with EphB receptors is required for the onset of different forms of persistent pain (both inflammatory and neuropathic).
EphB Binding (interaction) of ephrinB2 associated with pain, inflammation, lasting pain and neuropathic pain
2) Confidence 0.02 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.36 Pain Relevance 1.08

General Comments

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