INT249487

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ephb1, Src) plasma membrane (Ephb1, Src) endosome (Ephb1)
mitochondrion (Src) enzyme binding (Src) response to stress (Src)
Anatomy Link Frequency
spinal cord 1
dorsal horns 1
Ephb1 (Rattus norvegicus)
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 60 98.78 Very High Very High Very High
nMDA receptor 56 97.00 Very High Very High Very High
nMDA receptor antagonist 4 94.84 High High
Thermal hyperalgesia 26 90.12 High High
intrathecal 32 87.16 High High
Dorsal horn 22 85.32 High High
allodynia 14 80.40 Quite High
Eae 20 78.48 Quite High
Pain 12 66.56 Quite High
Hippocampus 10 66.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 28 93.68 High High
Hyperalgesia 50 90.12 High High
Neuropathic Pain 36 80.40 Quite High
Inflammatory Pain 14 78.48 Quite High
Pain 26 66.56 Quite High
INFLAMMATION 18 55.00 Quite High
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism apparently involved Src family kinases, since the level of phospho-Src bound to EphB receptors in the dorsal horns of the spinal cord was increased.
EphB Binding (bound) of phospho-Src in dorsal horns associated with spinal cord
1) Confidence 0.17 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.65 Pain Relevance 1.06
We have recently shown in the spinal cord an increase in the state of phosphorylation of non-receptor Src-family tyrosine kinases which were bound to EphB receptors “pulled-down” following ephrinB2 treatment (Battaglia et al., 2003).
EphB Binding (bound) of Src in spinal cord associated with spinal cord
2) Confidence 0.15 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.09 Pain Relevance 0.17

General Comments

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