INT249489

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Src, Grin2b) mitochondrion (Src) embryo development (Grin2b)
enzyme binding (Src) response to stress (Src) cytoplasm (Src)
Src (Rattus norvegicus)
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 13 99.82 Very High Very High Very High
intrathecal 16 97.14 Very High Very High Very High
nMDA receptor 28 91.96 High High
Glutamate 3 85.60 High High
Spinal cord 30 80.60 Quite High
Inflammation 9 75.00 Quite High
allodynia 7 73.04 Quite High
Hyperalgesia 11 71.92 Quite High
Dorsal horn 11 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 25 99.82 Very High Very High Very High
Nociception 14 83.20 Quite High
INFLAMMATION 9 75.00 Quite High
Neuropathic Pain 18 73.04 Quite High
Pain 13 5.00 Very Low Very Low Very Low
Inflammatory Pain 7 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal administration of ephrinB2-Fc in adult rats, which can bind to and activate EphB receptors and induce behavioral thermal hyperalgesia, led to NR2B tyrosine phosphorylation, which could be blocked by the Src family kinase inhibitor PP2.
Src Negative_regulation (blocked) of Phosphorylation (phosphorylation) of NR2B associated with thermal hyperalgesia and intrathecal
1) Confidence 0.20 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2568875 Disease Relevance 0.63 Pain Relevance 0.66

General Comments

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