INT249491

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Efnb2, Src) mitochondrion (Src) enzyme binding (Src)
response to stress (Src) cytoplasm (Src) cell proliferation (Src)
Anatomy Link Frequency
spinal cord 2
Efnb2 (Rattus norvegicus)
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 32 98.72 Very High Very High Very High
Spinal cord 60 95.84 Very High Very High Very High
nMDA receptor 56 94.68 High High
Thermal hyperalgesia 26 93.04 High High
Pain 12 92.84 High High
nMDA receptor antagonist 4 85.28 High High
Glutamate receptor 4 79.68 Quite High
Lasting pain 14 76.80 Quite High
Dorsal horn 22 58.32 Quite High
Hyperalgesia 22 55.88 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 50 93.04 High High
Pain 26 92.84 High High
Nociception 28 73.20 Quite High
INFLAMMATION 18 52.56 Quite High
Neuropathic Pain 36 44.72 Quite Low
Inflammatory Pain 14 39.60 Quite Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecally administered ephrinB2 induces NR2B phosphorylation via Src
ephrinB2 Positive_regulation (induces) of Phosphorylation (phosphorylation) of Src
1) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.17 Pain Relevance 0.28
Interestingly, Takasu et al. (2002) showed that in primary cortical neurons in culture EphB activation by ephrinB2-Fc (immunoglobulin Fc fusion protein of ephrinB2) induced Src-dependent NR2B phosphorylation and furthermore we showed that intrathecal injection of ephrinB2-Fc induces Src phosphorylation in the spinal cord of adult rats (Battaglia et al., 2003).
ephrinB2 Positive_regulation (induced) of Phosphorylation (phosphorylation) of Src in spinal cord associated with spinal cord and intrathecal
2) Confidence 0.01 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.33 Pain Relevance 0.58

General Comments

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