INT249498

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Src, Grin2b) mitochondrion (Src) embryo development (Grin2b)
enzyme binding (Src) response to stress (Src) cytoplasm (Src)
Src (Rattus norvegicus)
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 56 100.00 Very High Very High Very High
intrathecal 32 97.52 Very High Very High Very High
Glutamate 6 96.16 Very High Very High Very High
Thermal hyperalgesia 26 92.64 High High
Spinal cord 60 91.16 High High
central sensitization 10 86.72 High High
Pain 12 84.92 Quite High
Hyperalgesia 22 79.88 Quite High
Dorsal horn 22 79.88 Quite High
Hippocampus 10 78.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 28 93.76 High High
Hyperalgesia 50 92.64 High High
Pain 26 84.92 Quite High
Inflammatory Pain 14 75.72 Quite High
INFLAMMATION 18 75.00 Quite High
Neuropathic Pain 36 74.44 Quite High
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we provide more direct evidence supporting the hypothesis of a role of EphB receptors in physiological synaptic plasticity in vivo, via modulation of NMDA receptor activity, and in particular via Src-mediated phosphorylation of the NR2B subunit.
Src Positive_regulation (mediated) of Phosphorylation (phosphorylation) of NR2B associated with nmda receptor
1) Confidence 0.22 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.60 Pain Relevance 0.97
In particular, EphB receptor activation would induce phosphorylation of the NR2B subunit of the NMDA receptor by a Src family non-receptor tyrosine kinase.
Src Positive_regulation (induce) of Phosphorylation (phosphorylation) of NR2B associated with nmda receptor
2) Confidence 0.19 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2568875 Disease Relevance 0.51 Pain Relevance 0.57

General Comments

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