INT249499

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ephb1, Efnb2) endosome (Ephb1) signal transduction (Ephb1)
cell adhesion (Efnb2) cytoplasm (Ephb1)
Anatomy Link Frequency
nociceptors 1
Ephb1 (Rattus norvegicus)
Efnb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 16 91.64 High High
nociceptor 2 91.44 High High
Dorsal horn neuron 6 89.28 High High
Inflammation 9 87.72 High High
Root ganglion neuron 3 74.72 Quite High
Pain 6 63.40 Quite High
allodynia 7 51.60 Quite High
Hyperalgesia 11 51.04 Quite High
Thermal hyperalgesia 13 46.84 Quite Low
nMDA receptor 28 45.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 87.72 High High
Nociception 14 87.68 High High
Injury 5 87.08 High High
Nervous System Injury 3 85.88 High High
Ganglion Cysts 5 77.28 Quite High
Pain 13 63.40 Quite High
Neuropathic Pain 18 51.60 Quite High
Hyperalgesia 25 51.04 Quite High
Inflammatory Pain 7 10.40 Low Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While activation of ephrinB2 by EphB1 in intact animals does not appear to occur, or if it does occur it appears to have no functional consequences, since we (Battaglia et al., 2003) observed no change in thermal and mechanical sensitivity after intrathecal administration of EphB1 in control rats, it is possible that in animals sensitized by inflammation or injury retrograde signaling in nociceptors does take place.
EphB1 Positive_regulation (activation) of ephrinB2 in nociceptors associated with inflammation, nociceptor, injury and intrathecal
1) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.95 Pain Relevance 0.54

General Comments

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