INT249510

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fyn) endosome (Fyn) mitochondrion (Fyn)
plasma membrane (Fyn)
Anatomy Link Frequency
spinal cord 1
Fyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 28 99.52 Very High Very High Very High
Eae 10 98.72 Very High Very High Very High
Spinal cord 30 91.16 High High
Glutamate 3 77.72 Quite High
Inflammation 9 50.00 Quite Low
Hippocampus 5 49.92 Quite Low
Thermal hyperalgesia 13 18.64 Low Low
Hyperalgesia 11 15.28 Low Low
intrathecal 16 14.04 Low Low
Dorsal horn 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 7 98.72 Very High Very High Very High
Congenital Anomalies 1 59.56 Quite High
Targeted Disruption 2 58.08 Quite High
INFLAMMATION 9 50.00 Quite Low
Hyperalgesia 25 18.64 Low Low
Neuropathic Pain 18 5.00 Very Low Very Low Very Low
Nociception 14 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence exists for a role at least of Fyn and Src in NMDA receptor phosphorylation (Salter and Kalia, 2004), therefore we cannot exclude that a combination of at least these two Src family kinases is responsible for ephrinB2-mediated NR2B phosphorylation in our spinal cord plasticity model.
Localization (least) of Fyn in spinal cord associated with nmda receptor and spinal cord
1) Confidence 0.32 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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