INT249527

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
cleavage 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 72 100.00 Very High Very High Very High
Thermal hyperalgesia 13 99.84 Very High Very High Very High
intrathecal 16 94.20 High High
Inflammation 15 91.68 High High
Dorsal horn neuron 6 91.00 High High
Hyperalgesia 11 90.64 High High
allodynia 7 89.28 High High
Dorsal horn 11 88.08 High High
Lasting pain 7 80.08 Quite High
Neuropathic pain 9 75.76 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 25 99.84 Very High Very High Very High
INFLAMMATION 16 91.68 High High
Neuropathic Pain 18 89.28 High High
Pain 13 80.08 Quite High
Depression 44 74.08 Quite High
Inflammatory Pain 7 66.00 Quite High
Ganglion Cysts 5 60.20 Quite High
Nociception 14 59.36 Quite High
Injury 7 45.36 Quite Low
Nervous System Injury 3 20.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Src phosphorylation is required for phosphorylation of the NR2B subunit of the NMDA receptor and for induction of thermal hyperalgesia by ephrinB2.
Positive_regulation (required) of Positive_regulation (induction) of NR2B associated with thermal hyperalgesia and nmda receptor
1) Confidence 0.37 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.99 Pain Relevance 0.94
Western blot analysis found that UCB (10 ┬ÁM) treatment significantly induced a time-dependent increase in spectrin and NR2B subunit cleavage compared with control slices (Figure 9A).
Positive_regulation (induced) of Positive_regulation (increase) of NR2B in cleavage
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.13 Pain Relevance 0.28

General Comments

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