INT249530

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
neurons 4
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 7 99.96 Very High Very High Very High
intrathecal 32 99.38 Very High Very High Very High
nMDA receptor 87 99.04 Very High Very High Very High
Dorsal horn neuron 12 97.78 Very High Very High Very High
Dorsal horn 22 96.32 Very High Very High Very High
Thermal hyperalgesia 26 86.88 High High
Inflammation 18 85.40 High High
Lasting pain 14 84.64 Quite High
Hyperalgesia 22 82.88 Quite High
Neuropathic pain 18 80.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 50 86.88 High High
Neuropathic Pain 36 86.04 High High
INFLAMMATION 18 85.40 High High
Pain 26 84.64 Quite High
Depression 8 75.24 Quite High
Inflammatory Pain 14 70.56 Quite High
Ganglion Cysts 10 64.76 Quite High
Nociception 28 63.92 Quite High
Injury 10 39.76 Quite Low
Congenital Anomalies 2 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NMDA receptor currents must be further enhanced during the high frequency stimulation by the calcium-dependent activation of Pyk2 and Src kinases in order to induce LTP [5].
Positive_regulation (induce) of Positive_regulation (activation) of Src associated with nmda receptor and long-term potentiation
1) Confidence 0.28 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.60
Indeed, EphB2 activation of Src by phosphorylation in cultured hippocampal and cortical neurons could induce NR2A phosphorylation (Grunwald et al., 2001).
Positive_regulation (induce) of Positive_regulation (activation) of Src in neurons
2) Confidence 0.24 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.15 Pain Relevance 0.33
Our findings (Battaglia et al., 2003, and present work) support the idea of an activation by ephrinB2 of postsynaptic EphB receptors in neurons of the dorsal horn, since we showed that EphB1 receptors are present in dorsal horn neurons, where they are found in close association with NMDA receptors, and intrathecal administration of ephrinB2-Fc induces an increase in phosphorylated Src kinase associated with the EphB receptor itself.
Positive_regulation (induces) of Positive_regulation (increase) of Src in neurons associated with nmda receptor, dorsal horn, dorsal horn neuron and intrathecal
3) Confidence 0.22 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.02 Pain Relevance 0.96

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox