INT24956

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2007
Negated 1
Speculated 5
Reported most in Abstract
Documents 22
Total Number 27
Disease Relevance 7.21
Pain Relevance 13.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tacr3) plasma membrane (Tacr3) nucleus (Tacr3)
cytoplasm (Tacr3) signal transducer activity (Tacr3)
Anatomy Link Frequency
neurons 6
spinal cord 3
myometrium 2
dorsal horn 2
sensory neurons 1
Tacr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 119 100.00 Very High Very High Very High
agonist 21 100.00 Very High Very High Very High
opioid receptor 20 100.00 Very High Very High Very High
Pain 31 99.82 Very High Very High Very High
opiate 12 99.58 Very High Very High Very High
Spinal cord 45 99.52 Very High Very High Very High
Dorsal horn 33 99.04 Very High Very High Very High
qutenza 9 98.56 Very High Very High Very High
Neuropeptide 8 98.16 Very High Very High Very High
spinal dorsal horn 4 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 49 99.92 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 99.44 Very High Very High Very High
Pain 12 99.24 Very High Very High Very High
Infection 2 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 8 97.60 Very High Very High Very High
INFLAMMATION 20 96.48 Very High Very High Very High
Pancreatitis 8 94.88 High High
Low Back Pain 4 93.08 High High
Urological Neuroanatomy 8 90.72 High High
Heart Rate Under Development 6 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptors for neurokinin 1 (NK1-R), neurokinin 2 (NK2-R), and neurokinin 3 (NK3-R) are expressed and functionally active in the uterus, promoting strong contractions of the myometrium.
Gene_expression (expressed) of neurokinin 3 in myometrium
1) Confidence 0.74 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 12390879 Disease Relevance 0.05 Pain Relevance 0.05
The receptors for neurokinin 1 (NK1-R), neurokinin 2 (NK2-R), and neurokinin 3 (NK3-R) are expressed and functionally active in the uterus, promoting strong contractions of the myometrium.
Gene_expression (expressed) of NK3-R in myometrium
2) Confidence 0.74 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 12390879 Disease Relevance 0.05 Pain Relevance 0.05
Second, the relationship between NK3/MOR1-coexpressing neurons and those that express nitric oxide synthase (NOS) was examined by using a triple immunofluorescent staining method.
Gene_expression (coexpressing) of NK3 in neurons associated with opioid receptor
3) Confidence 0.73 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12193200 Disease Relevance 0.08 Pain Relevance 0.52
Two major distinct subpopulations of neurokinin-3 receptor-expressing neurons in the superficial dorsal horn of the rat spinal cord.
Gene_expression (expressing) of neurokinin-3 receptor in dorsal horn associated with pain, dorsal horn and spinal cord
4) Confidence 0.73 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12193200 Disease Relevance 0.09 Pain Relevance 0.73
The present results indicate that there are two major distinct subpopulations of NK3-expressing neurons in the superficial dorsal horn, which suggests that the involvement of NK3 receptor in spinal nociception could be mediated by two distinct mechanisms, i.e. opioid and nitric oxide.
Gene_expression (expressing) of NK3-expressing in dorsal horn associated with nociception, dorsal horn and opioid
5) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12193200 Disease Relevance 0.16 Pain Relevance 0.51
Confocal microscopy showed that about 44% of NK3-expressing neurons in laminae I and II were immunoreactive for MOR1, which corresponded to about 93% of the total population of MOR1-containing neurons in these laminae.
Gene_expression (expressing) of NK3-expressing in neurons associated with opioid receptor
6) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12193200 Disease Relevance 0.09 Pain Relevance 0.45
Additionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the neurokinin 3 receptor (NK3R) or nuclear estrogen receptor-alpha (ERalpha).
Spec (whether) Gene_expression (expressed) of NK3R in neurons
7) Confidence 0.60 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16917850 Disease Relevance 0 Pain Relevance 0.08
Interestingly, the majority of prodynorphin-ir neurons in the arcuate nucleus expressed NK3R, and nearly 100% of the prodynorphin-ir neurons contained nuclear ERalpha.
Gene_expression (expressed) of NK3R in neurons
8) Confidence 0.60 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16917850 Disease Relevance 0.09 Pain Relevance 0.08
Additionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the neurokinin 3 receptor (NK3R) or nuclear estrogen receptor-alpha (ERalpha).
Spec (whether) Gene_expression (expressed) of neurokinin 3 receptor in neurons
9) Confidence 0.60 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16917850 Disease Relevance 0 Pain Relevance 0.08
This study investigated changes in NK-1 and NK-3 receptor mRNA expression during nociception.
Spec (investigated) Gene_expression (expression) of NK-3 receptor mRNA associated with nociception
10) Confidence 0.47 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.34 Pain Relevance 0.61
NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception.
Gene_expression (expression) of NK-3 in spinal cord dorsal horn associated with nociception, pain, dorsal horn and spinal cord
11) Confidence 0.47 Published 1994 Journal J. Neurosci. Section Title Doc Link 8301359 Disease Relevance 0.34 Pain Relevance 0.70
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Gene_expression (expression) of NK-3 in dorsal root ganglia associated with dorsal horn and spinal cord
12) Confidence 0.41 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.33 Pain Relevance 0.68
Previous studies in vitro have shown that NK3 receptors exist on primary afferent terminals in rat spinal cord and mediate potentiation of the depolarisation-evoked substance P (SP) release.
Gene_expression (exist) of NK3 in spinal cord associated with substance p and spinal cord
13) Confidence 0.39 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665827 Disease Relevance 0.32 Pain Relevance 0.62
The drop in MAP produced by the NK-1 and NK-3 agonists were reduced by hexamethonium, methylatropine and bilateral vagotomy (NK-3 agonist), but remained unaffected by indomethacin, capsaicin, and compound 48/80.
Gene_expression (produced) of NK-3 associated with qutenza and agonist
14) Confidence 0.34 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2482449 Disease Relevance 0.49 Pain Relevance 0.87
Neurokinin-3 receptor messenger RNA expression levels varied closely with, and thus may be regulated by, the levels of neurokinin B messenger RNA in the same regions.
Gene_expression (expression) of Neurokinin-3 receptor
15) Confidence 0.32 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.32 Pain Relevance 0.74
Measurable levels of neurokinin-3 receptor messenger RNA were found only in brain, spinal cord and urinary bladder.
Gene_expression (levels) of neurokinin-3 receptor messenger RNA in brain associated with spinal cord
16) Confidence 0.29 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.27 Pain Relevance 0.49
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons.
Gene_expression (expression) of neurokinin-3 receptor in sensory neurons associated with inflammation and substance p
17) Confidence 0.29 Published 1999 Journal Neuroscience Section Title Doc Link 10430499 Disease Relevance 0.39 Pain Relevance 0.42
The expression of neurokinin-1 and neurokinin-3 receptor messenger RNAs in the spinal cord is increased following intense nociception.
Gene_expression (expression) of neurokinin-3 receptor in spinal cord associated with nociception and spinal cord
18) Confidence 0.24 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.35 Pain Relevance 0.77
This study investigated whether these opiates similarly alter the expression of substance P-, neurokinin B-, neurokinin-1 receptor- and neurokinin-3 receptor-encoding messenger RNAs in spinal systems following formalin-induced nociception.
Spec (whether) Gene_expression (expression) of neurokinin-3 receptor in spinal associated with nociception, opiate and substance p
19) Confidence 0.21 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.42 Pain Relevance 0.86
Measurable levels of neurokinin-3 receptor messenger RNA were found only in brain, spinal cord and urinary bladder.
Gene_expression (levels) of neurokinin-3 receptor messenger RNA in spinal cord associated with spinal cord
20) Confidence 0.10 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.27 Pain Relevance 0.49

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