INT249561

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.32
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Psmd1) cellular_component (Psmd1)
Anatomy Link Frequency
Notch 1
Daoy 1
spleen 1
Psmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 352 100.00 Very High Very High Very High
primary somatosensory cortex 224 100.00 Very High Very High Very High
Anterior cingulate cortex 268 99.80 Very High Very High Very High
opioid receptor 84 99.14 Very High Very High Very High
Antinociceptive 36 98.90 Very High Very High Very High
fluoxetine 47 95.32 Very High Very High Very High
c fibre 20 94.76 High High
analgesia 16 93.68 High High
Opioid 72 91.92 High High
Analgesic 24 91.36 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 41 99.96 Very High Very High Very High
Targeted Disruption 389 99.68 Very High Very High Very High
Stress 122 99.28 Very High Very High Very High
Stomach Cancer 53 98.80 Very High Very High Very High
Anorexia 15 96.72 Very High Very High Very High
Neutropenia 9 92.80 High High
Hyperalgesia 16 90.96 High High
Pain 50 89.92 High High
Solid Tumor 5 89.16 High High
Aggression 10 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced antinociceptive effect during behavioral tests was also observed as a result of the suppression of evoked synaptic currents in the S1 of the KO mice.
Positive_regulation (result) of S1 associated with targeted disruption, primary somatosensory cortex and antinociceptive
1) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.49 Pain Relevance 1.74
Evoked responses in S1 following laser stimulation
Positive_regulation (stimulation) of S1 associated with primary somatosensory cortex
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.91 Pain Relevance 0.59
Thus, up-regulation of opioid receptors may only be partially responsible for the increase in sensitivity to exogenous morphine treatment and the potentiated morphine effect in both the S1 and ACC.
Positive_regulation (increase) of S1 associated with primary somatosensory cortex, opioid receptor, anterior cingulate cortex and morphine
3) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.29 Pain Relevance 1.48
Laser evoked CSD in the S1
Positive_regulation (evoked) of S1 associated with primary somatosensory cortex
4) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.92 Pain Relevance 0.45
These results demonstrate that the loss of GluR2 in CA1 selectively impairs context fear (see Text S1 for a more detailed discussion).
Positive_regulation (see) of Text S1 associated with anxiety disorder
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 1.10 Pain Relevance 0.27
Since the four genes encompassed by the chromosomal deletion appeared to be transcriptionaly active in organs highly enriched with hematopoietic cells such as the fetal liver, the bone marrow, the spleen, and the thymus (Figures 1B and S1), a functional characterization of the hematological system was performed.
Positive_regulation (active) of S1 in spleen
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759285 Disease Relevance 0.29 Pain Relevance 0
This prevents activation of the Notch response (see Text S1, Materials), thus blocking the presenilin-secretase complex and enhancing miR199b-5p expression [50], [51].
Positive_regulation (activation) of S1 in Notch
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.78 Pain Relevance 0
Similar results were obtained in Daoy MB cells (Text S1, Fig.
Positive_regulation (results) of S1 in Daoy
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.17 Pain Relevance 0
During the first UCMS procedure, the total grooming time increased between the beginning (Session S1) and the end (Session S2) of the regimen in each group suggesting an increase in the motivation for grooming and the fact that the mice became used to the sucrose solution (Figure 3A, Control/NaCl: RD: T?
Positive_regulation (increased) of S1 associated with stress
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861008 Disease Relevance 0.79 Pain Relevance 0.52
In our previous report,5 we evaluated S-1, S-1 plus cisplatin, and paclitaxel as chemotherapeutic regimens for treatment of advanced gastric cancer by measuring the objective response rate (RR), overall survival, and the safety profile, for the use of these therapies as first, second, and third line chemotherapeutic regimens.
Positive_regulation (evaluated) of S-1 associated with stomach cancer
10) Confidence 0.17 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883242 Disease Relevance 0.40 Pain Relevance 0
In our previous report,5 we evaluated S-1, S-1 plus cisplatin, and paclitaxel as chemotherapeutic regimens for treatment of advanced gastric cancer by measuring the objective response rate (RR), overall survival, and the safety profile, for the use of these therapies as first, second, and third line chemotherapeutic regimens.
Positive_regulation (evaluated) of S-1 associated with stomach cancer
11) Confidence 0.17 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883242 Disease Relevance 0.40 Pain Relevance 0
Since this report, many institutions in Japan have implemented S-1 plus cisplatin as first line chemotherapy for advanced and recurrent gastric cancer.
Positive_regulation (implemented) of S-1 associated with stomach cancer
12) Confidence 0.17 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883242 Disease Relevance 0.79 Pain Relevance 0

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