INT249562

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.20
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Psmd1) cellular_component (Psmd1)
Psmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 176 100.00 Very High Very High Very High
primary somatosensory cortex 112 100.00 Very High Very High Very High
Anterior cingulate cortex 134 99.80 Very High Very High Very High
opioid receptor 42 99.54 Very High Very High Very High
Opioid 36 91.92 High High
Analgesic 12 83.52 Quite High
antagonist 12 82.88 Quite High
Enkephalin 66 79.12 Quite High
mu opioid receptor 2 65.16 Quite High
withdrawal 34 51.24 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 190 95.36 Very High Very High Very High
Nociception 60 80.72 Quite High
Urological Neuroanatomy 2 12.16 Low Low
Pain 22 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evoked responses in S1 following laser stimulation
Regulation (responses) of Positive_regulation (stimulation) of S1 associated with primary somatosensory cortex
1) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.91 Pain Relevance 0.60
Thus, up-regulation of opioid receptors may only be partially responsible for the increase in sensitivity to exogenous morphine treatment and the potentiated morphine effect in both the S1 and ACC.
Spec (partially) Regulation (responsible) of Positive_regulation (increase) of S1 associated with primary somatosensory cortex, opioid receptor, anterior cingulate cortex and morphine
2) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.29 Pain Relevance 1.49

General Comments

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