INT24958

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 106
Total Number 111
Disease Relevance 51.29
Pain Relevance 76.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
neurons 18
spinal 14
spinal cord 8
lamina 5
dorsal root ganglion 3
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2102 100.00 Very High Very High Very High
bradykinin 1224 100.00 Very High Very High Very High
Pain 950 100.00 Very High Very High Very High
nav1.8 455 100.00 Very High Very High Very High
agonist 341 100.00 Very High Very High Very High
Kinase C 309 100.00 Very High Very High Very High
tetrodotoxin 120 100.00 Very High Very High Very High
nMDA receptor 91 100.00 Very High Very High Very High
sodium channel 35 100.00 Very High Very High Very High
Somatostatin 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1302 99.96 Very High Very High Very High
Nociception 592 99.96 Very High Very High Very High
Injury 63 99.92 Very High Very High Very High
Respiratory Syncytial Virus 16 99.82 Very High Very High Very High
Arthritis 1215 99.52 Very High Very High Very High
Pain 927 99.40 Very High Very High Very High
Inflammatory Pain 79 99.28 Very High Very High Very High
Urological Neuroanatomy 22 99.16 Very High Very High Very High
Coronary Artery Disease 8 99.04 Very High Very High Very High
INFLAMMATION 1029 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity of neurokinin-1 (NK-1) receptor-expressing ascending spinal neurons, descending pathways originating in the rostral ventromedial medulla (RVM), and spinal dynorphin are necessary for the development and maintenance of hyperalgesia during sustained morphine exposure, suggesting that these mechanisms may also be important in opioid enhancement of surgical pain.
Gene_expression (expressing) of NK-1 in neurons associated with pain, hyperalgesia, dynorphin, opioid, morphine and rostral ventromedial medulla
1) Confidence 0.74 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200067 Disease Relevance 0.72 Pain Relevance 0.90
The nociceptive nature of spinal dorsal horn neurons expressing NK1 and gamma-aminobutyric acid (GABA)(B) receptors was evaluated in the rat.
Gene_expression (expressing) of NK1 in spinal associated with nociception, gaba and dorsal horn neuron
2) Confidence 0.71 Published 2004 Journal Brain Res. Section Abstract Doc Link 15019566 Disease Relevance 0.17 Pain Relevance 0.20
Nociceptive spinal neurons expressing NK1 and GABAB receptors are located in lamina I.
Gene_expression (expressing) of NK1 in lamina associated with pain
3) Confidence 0.71 Published 2004 Journal Brain Res. Section Title Doc Link 15019566 Disease Relevance 0.25 Pain Relevance 0.51
NK-1 receptors were tagged immunohistochemically and their distribution quantified by use of computer-assisted image analysis.
Gene_expression (tagged) of NK-1
4) Confidence 0.66 Published 2001 Journal Somatosens Mot Res Section Abstract Doc Link 11327573 Disease Relevance 1.30 Pain Relevance 0.94
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, preferentially reduced the after-discharges, demonstrating that NK-1 and NMDA receptors mediate the after-discharges.
Gene_expression (mediate) of NK-1 associated with ketamine, nmda receptor and antagonist
5) Confidence 0.66 Published 2006 Journal Brain Res. Section Abstract Doc Link 16507302 Disease Relevance 0.21 Pain Relevance 0.91
The results suggest involvement of NK-1 receptors expressed on the peripheral afferent terminals in thermal hyperalgesia mediated by directly sensitizing C-type sensory afferents.
Gene_expression (expressed) of NK-1 associated with thermal hyperalgesia
6) Confidence 0.65 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16300741 Disease Relevance 0.67 Pain Relevance 0.51
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.
Gene_expression (expressing) of NK-1 in neurons associated with hypersensitivity, stimulus evoked pain and perioperative pain
7) Confidence 0.65 Published 2009 Journal Eur. J. Neurosci. Section Title Doc Link 19200067 Disease Relevance 0.87 Pain Relevance 0.96
At 48 h following hindpaw inflammation with complete Freund's adjuvant, the proportion of unmyelinated axons expressing NK1 receptors significantly increases to 23.6%.
Gene_expression (expressing) of NK1 associated with inflammation and unmyelinated
8) Confidence 0.64 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12052531 Disease Relevance 0.42 Pain Relevance 0.57
As to the morphological lamina I cell class, NK1-positive cells belonged mainly to the fusiform type while similar proportions of fusiform, pyramidal and flattened NK1 neurons expressed GABA(B) receptors.
Gene_expression (expressed) of NK1 in neurons associated with gaba
9) Confidence 0.62 Published 2004 Journal Brain Res. Section Abstract Doc Link 15019566 Disease Relevance 0.23 Pain Relevance 0.43
METHODS: Rats were treated intraperitoneally and intrathecally with peripherally restricted (SR140333) or blood-brain barrier-penetrating (L-733,060) NK1 receptor antagonists and were evaluated for paw pressure thresholds, numbers of infiltrating opioid-containing leukocytes and leukocyte subpopulations, expression of adhesion molecules, NK1 receptors, and chemokines 24-48 h after complete Freund adjuvant-induced hind paw inflammation.
Gene_expression (expression) of NK1 in brain
10) Confidence 0.61 Published 2007 Journal Anesthesiology Section Body Doc Link 18043070 Disease Relevance 0.09 Pain Relevance 0
NK1 receptors were expressed on peripheral neurons, infiltrating leukocytes and endothelial cells.
Gene_expression (expressed) of NK1 in leukocytes
11) Confidence 0.61 Published 2007 Journal Anesthesiology Section Body Doc Link 18043070 Disease Relevance 0.06 Pain Relevance 0
The percentage of Fos-positive cells expressing NK1 immunoreaction did not change in monoarthritics but that of Fos cells with GABA(B) immunoreaction was lower in these animals.
Gene_expression (expressing) of NK1 associated with gaba
12) Confidence 0.57 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857696 Disease Relevance 0.43 Pain Relevance 0.46
Imbalance between the expression of NK1 and GABAB receptors in nociceptive spinal neurons during secondary hyperalgesia: a c-Fos study in the monoarthritic rat.
Gene_expression (expression) of NK1 in spinal associated with nociception, hyperalgesia and nociceptor
13) Confidence 0.57 Published 2005 Journal Neuroscience Section Title Doc Link 15857696 Disease Relevance 0.55 Pain Relevance 0.55
In lamina I, the percentage of NK1 neurons expressing Fos was higher in monoarthritics while lower percentages of GABA(B) neurons expressed Fos.
Gene_expression (expressing) of NK1 in lamina associated with gaba
14) Confidence 0.57 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857696 Disease Relevance 0.45 Pain Relevance 0.47
In this study we evaluated the expression of NK1 and GABA(B) receptors in nociceptive spinal neurons in a model of secondary hyperalgesia consisting of noxious mechanical stimulation of the hindlimb skin close to a joint chronically inflamed by complete Freund's adjuvant.
Gene_expression (expression) of NK1 in spinal associated with nociception, hyperalgesia and gaba
15) Confidence 0.57 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857696 Disease Relevance 0.53 Pain Relevance 0.40
The present results suggest that the expression of NK1 and GABAB receptors varies in neurones participating to different spinofugal pathways.
Gene_expression (expression) of NK1
16) Confidence 0.57 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16564421 Disease Relevance 0.07 Pain Relevance 0.33
Differential expression of NK1 and GABAB receptors in spinal neurones projecting to antinociceptive or pronociceptive medullary centres.
Gene_expression (expression) of NK1 in spinal associated with nociceptor and antinociceptive
17) Confidence 0.57 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 16564421 Disease Relevance 0.07 Pain Relevance 0.38
We compared the relative expression of NK1 and GABAB receptors in two spinomedullary pathways targeting an antinociceptive area and a pronociceptive centre, respectively, the lateral part of the caudal ventrolateral medulla (VLMlat) and the dorsal reticular nucleus (DRt).
Gene_expression (expression) of NK1 in lateral associated with medulla and antinociceptive
18) Confidence 0.57 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16564421 Disease Relevance 0.07 Pain Relevance 0.25
Accordingly, the present study demonstrates that 15.6% of unmyelinated primary afferent axons in rat glabrous skin express the neurokinin 1 (NK1) receptor.
Gene_expression (express) of NK1 in skin associated with unmyelinated
19) Confidence 0.56 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12052531 Disease Relevance 0.40 Pain Relevance 0.55
Antagonizing peripheral NK1 receptors locally would be effective in reducing inflammatory pain by reducing neural transduction in NK1-expressing nociceptors as well as lessening the inflammatory vascular effects of peripheral substance P.
Gene_expression (expressing) of NK1-expressing in nociceptors associated with inflammation, nociceptor, ipn and substance p
20) Confidence 0.55 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12052531 Disease Relevance 0.52 Pain Relevance 0.60

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