INT24959

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Context Info
Confidence 0.20
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.64
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
spinal cord 2
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 17 100.00 Very High Very High Very High
Spinal cord 46 99.68 Very High Very High Very High
gABA 5 99.58 Very High Very High Very High
bradykinin 40 98.92 Very High Very High Very High
qutenza 4 98.56 Very High Very High Very High
b2 receptor 10 96.76 Very High Very High Very High
Lasting pain 25 96.20 Very High Very High Very High
analgesia 2 95.16 Very High Very High Very High
Hippocampus 52 90.96 High High
Antinociceptive 1 89.12 High High
Disease Link Frequency Relevance Heat
Stress 20 99.18 Very High Very High Very High
Pain 63 96.20 Very High Very High Very High
Nociception 55 94.64 High High
Heart Rate Under Development 6 89.68 High High
Sleep Disorders 1 76.48 Quite High
Ataxia 1 75.68 Quite High
INFLAMMATION 45 43.12 Quite Low
Hyperalgesia 14 10.96 Low Low
Ganglion Cysts 107 5.00 Very Low Very Low Very Low
Arthritis 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord.
Negative_regulation (blockade) of Gene_expression (expression) of NK-1 in spinal cord associated with gaba and spinal cord
1) Confidence 0.20 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.40 Pain Relevance 0.82
The drop in MAP produced by the NK-1 and NK-3 agonists were reduced by hexamethonium, methylatropine and bilateral vagotomy (NK-3 agonist), but remained unaffected by indomethacin, capsaicin, and compound 48/80.
Negative_regulation (reduced) of Gene_expression (produced) of NK-1 associated with qutenza and agonist
2) Confidence 0.16 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2482449 Disease Relevance 0.49 Pain Relevance 0.87
Immunocytochemical labelling of NK1 and TRPV1 receptors
Negative_regulation (labelling) of Gene_expression (receptors) of NK1
3) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0 Pain Relevance 0.31
A similar type of hippocampal plasticity was previously observed after either peripheral formalin injections or immobilization stress, as both of these stimuli were shown to down-regulate hippocampal NK-1 and BDNF gene expression [36,38,41].
Negative_regulation (regulate) of Gene_expression (expression) of NK-1 associated with stress
4) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.88 Pain Relevance 0.70
A similar type of hippocampal plasticity was previously observed after either peripheral formalin injections or immobilization stress, as both of these stimuli were shown to down-regulate hippocampal NK-1 and BDNF gene expression [36,38,41].
Negative_regulation (down) of Gene_expression (expression) of NK-1 associated with stress
5) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.88 Pain Relevance 0.70

General Comments

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