INT249596

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
macrophages 2
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 85.68 High High
chemokine 3 74.88 Quite High
cytokine 28 72.12 Quite High
Inflammation 28 67.60 Quite High
Central nervous system 6 62.68 Quite High
Multiple sclerosis 1 60.40 Quite High
cINOD 1 60.00 Quite High
Inflammatory response 2 52.20 Quite High
Inflammatory stimuli 2 37.60 Quite Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 84.80 Quite High
Alzheimer's Dementia 3 82.72 Quite High
INFLAMMATION 34 67.60 Quite High
Neurodegenerative Disease 8 63.92 Quite High
Demyelinating Disease 1 60.40 Quite High
Motor Neuron Diseases 1 59.44 Quite High
Creutzfeldt Jakob Disease 1 58.20 Quite High
Disease 9 57.60 Quite High
Dementia 1 56.76 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Positive_regulation (increasing) of Gene_expression (expression) of ACAT-1 in macrophages
1) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14
Furthermore, it is well known that the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a central role in this IFN-?
Positive_regulation (activation) of Gene_expression (/) of STAT
2) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.96 Pain Relevance 0.28

General Comments

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