INT249600

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglia 2
IFNA1 (Homo sapiens)
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 93.28 High High
cytokine 8 92.24 High High
cINOD 2 75.36 Quite High
Central nervous system 12 53.40 Quite High
Multiple sclerosis 2 51.12 Quite High
Inflammatory response 2 42.92 Quite Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 98.08 Very High Very High Very High
INFLAMMATION 44 93.28 High High
Cancer 6 89.44 High High
Necrosis 4 88.96 High High
Neurodegenerative Disease 16 79.28 Quite High
Aging 2 54.00 Quite High
Demyelinating Disease 2 51.12 Quite High
Motor Neuron Diseases 2 50.16 Quite High
Creutzfeldt Jakob Disease 2 48.92 Quite Low
Disease 18 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that microglial CD40 expression is significantly increased by IFN-?
IFN Positive_regulation (increased) of Gene_expression (expression) of CD40
1) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.56 Pain Relevance 0.26
Our findings demonstrate that treatment of both N9 and murine-derived primary microglia cell lines with apigenin and luteolin significantly reduces CD40 expression induced by IFN-?.
IFN Positive_regulation (induced) of Gene_expression (expression) of CD40 in microglia
2) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.57 Pain Relevance 0.26

General Comments

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